HCV Core Genotype-3a
Description
Product Specs
Product Science Overview
Hepatitis C Virus (HCV) is a significant global health concern, infecting approximately 71 million people worldwide. It is a bloodborne virus primarily transmitted through exposure to infected blood. HCV is classified into seven genotypes, with genotype 3 being one of the most prevalent globally. Within genotype 3, subtype 3a is particularly notable for its unique characteristics and clinical implications.
HCV is an enveloped, positive-sense single-stranded RNA virus belonging to the Flaviviridae family. The viral genome encodes a single polyprotein, which is processed into structural and non-structural proteins. The core protein is one of the structural proteins and plays a crucial role in the formation of the viral nucleocapsid.
Genotype 3a is one of the most common HCV subtypes, especially prevalent in South Asia and among intravenous drug users in Western countries. It is associated with a higher rate of liver steatosis (fatty liver) and a faster progression to liver fibrosis and cirrhosis compared to other genotypes. Genotype 3a also responds differently to antiviral therapies, making its study essential for effective treatment strategies.
Recombinant HCV core proteins are artificially produced proteins that mimic the natural core protein of the virus. These recombinant proteins are used in various research and diagnostic applications. They are produced using genetic engineering techniques, where the gene encoding the core protein is inserted into a suitable expression system, such as bacteria or yeast, to produce the protein in large quantities.
- Diagnostic Tools: Recombinant HCV core proteins are used in enzyme immunoassays (EIAs) to detect antibodies against HCV in patient samples. These assays are crucial for the early diagnosis of HCV infection.
- Vaccine Development: Research is ongoing to develop vaccines against HCV. Recombinant core proteins are used to study the immune response and identify potential vaccine candidates.
- Therapeutic Research: Understanding the structure and function of the HCV core protein helps in the development of antiviral drugs. Recombinant proteins are used to screen for compounds that can inhibit the virus.
