HAVCR2 Human

The HAVCR2 gene encodes a protein that belongs to the immunoglobulin superfamily and the TIM family of proteins . The protein has a significant role in modulating both innate and adaptive immune responses. It is generally accepted to have an inhibitory function, although some reports suggest that its activity may be influenced by the cellular context and the respective ligand .

HAVCR2 is involved in regulating macrophage activation and inhibiting Th1-mediated auto- and alloimmune responses, thereby promoting immunological tolerance . This receptor is implicated in various immune pathways, including cytokine signaling in the immune system and interleukin-2 family signaling .

Diseases associated with HAVCR2 include T-cell lymphoma, subcutaneous panniculitis-like T-cell lymphoma, and hepatitis . The receptor’s role in these diseases highlights its importance in immune regulation and potential as a therapeutic target.

Recombinant forms of HAVCR2 are used in research to study its function and interactions. These recombinant proteins are typically produced in human cell lines to ensure proper folding and post-translational modifications, which are crucial for their biological activity .

Research on HAVCR2 has provided insights into its role in immune responses and its potential as a therapeutic target. For instance, studies have shown that HAVCR2 can regulate macrophage activation and inhibit Th1-mediated immune responses, which are critical for maintaining immune homeostasis .

In conclusion, HAVCR2 is a vital component of the immune system with significant implications for immune regulation and potential therapeutic applications. Its role in various diseases underscores the importance of continued research to fully understand its functions and mechanisms.