HAVCR2 Mouse
HEK293 cells.
Hepatitis A virus cellular receptor 2, HAVcr-2, T-cell immunoglobulin and mucin domain-containing protein 3, TIMD-3, T-cell membrane protein 3, TIM-3, HAVCR2, TIM3, TIMD3, TIM3, KIM-3
Sterile filtered colorless solution.
Greater than 95.0% as determined by SDS-PAGE.
Description
HAVCR2 Mouse Recombinant produced in HEK293 cells is a single, glycosylated polypeptide chain (20-193 a.a) containing 413 amino acids and having a molecular mass of 46.3kDa.
HAVCR2 is fused to a 239 amino acid hIgG-His-Tag at C-terminus & purified by proprietary chromatographic techniques.
Product Specs
Hepatitis A virus cellular receptor 2, HAVcr-2, T-cell immunoglobulin and mucin domain-containing protein 3, TIMD-3, T-cell membrane protein 3, TIM-3, HAVCR2, TIM3, TIMD3, TIM3, KIM-3
HEK293 cells.
RSLENAYVFE VGKNAYLPCS YTLSTPGALV PMCWGKGFCP WSQCTNELLR TDERNVTYQK SSRYQLKGDL NKGDVSLIIK NVTLDDHGTY CCRIQFPGLM NDKKLELKLD IKAAKVTPAQ TAHGDSTTAS PRTLTTERNG SETQTLVTLH NNNGTKISTW ADEIKDSGET IRTALEPKSC DKTHTCPPCP APELLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSHED PEVKFNWYVD GVEVHNAKTK PREEQYNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKALPA PIEKTISKAK GQPREPQVYT LPPSRDELTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSKL TVDKSRWQQG NVFSCSVMHE ALHNHYTQKS LSLSPGKHHH HHH
Product Science Overview
The HAVCR2 gene encodes a type I membrane protein that consists of an immunoglobulin variable-like (IgV) domain, a mucin-like domain, and a cytoplasmic domain with a tyrosine phosphorylation motif . The protein is approximately 301 amino acids in length and shares significant homology with the hepatitis A virus cellular receptor 1 (HAVCR1), also known as TIM-1 or Kim1 .
HAVCR2 is a critical negative regulator in the immune system, acting as a checkpoint in peripheral tolerance and innate immune and inflammatory responses . It is specifically expressed on activated Th1 cells and CD11b+ macrophages . The protein regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis (EAE) in mice .
HAVCR2 is related to the hepatitis A virus cellular receptor (HAVCR1), which the hepatitis A virus (HAV) uses to infect cells . The interaction of HAV with soluble forms of its cellular receptor shares the physiological requirements of infectivity in cell culture . This interaction is crucial for understanding the cell entry process of HAV and its pathogenesis .
Recombinant forms of HAVCR2, such as the mouse recombinant version, are used in research to study its function and interaction with various ligands. These recombinant proteins are valuable tools for investigating the molecular mechanisms underlying immune responses and viral infections.
The role of HAVCR2 in regulating immune responses makes it a potential target for therapeutic interventions in autoimmune diseases and cancer. By modulating the activity of HAVCR2, it may be possible to enhance immune responses against tumors or reduce inflammation in autoimmune conditions.
