GH Mouse

GH belongs to the somatotropin/prolactin family of hormones, which are essential for growth control . The gene encoding GH, along with four other related genes, is located at the growth hormone locus on chromosome 17. These genes share a high degree of sequence identity, which is believed to have evolved through a series of gene duplications . Alternative splicing of these genes generates multiple isoforms, adding to the diversity and specialization of growth hormones .

In mice, GH is primarily expressed in the pituitary gland and is not found in placental tissue, unlike some other members of the growth hormone family . GH exerts its effects by binding to the growth hormone receptor (GHR), which triggers a cascade of downstream signaling pathways that promote growth and metabolic processes .

Recombinant mouse GH is produced using an expression system in Escherichia coli (E. coli) . The recombinant protein is typically purified to a high degree of purity (>95%) and is biologically active, comparable to standard human growth hormone . The molecular weight of recombinant mouse GH is approximately 22 kDa, and it is often formulated in a lyophilized form for stability and ease of use .

Recombinant mouse GH is widely used in various research applications, including:

• Growth and Development Studies: Understanding the role of GH in growth regulation and developmental processes.
• Metabolic Research: Investigating the effects of GH on metabolism, including its impact on glucose and lipid metabolism.
• Endocrine Studies: Exploring the interactions between GH and other hormones in the endocrine system.
• Disease Models: Studying the effects of GH deficiency or excess in animal models to better understand related human conditions .

Recombinant mouse GH is stable for up to six months when stored at -70°C or -20°C. Upon reconstitution, it remains stable for up to one week at 4°C or up to three months at -20°C, provided that repeated freeze-thaw cycles are avoided .