GADD45G Human
Description
Product Specs
To ensure long-term stability, the addition of a carrier protein (either HSA or BSA) at a concentration of 0.1% is advised.
Repeated freezing and thawing of the product should be avoided.
Product Science Overview
The GADD45G gene is located on chromosome 9 in humans . It is also known by several aliases, including CR6, DDIT2, GRP17, and OIG37 . The protein encoded by this gene is involved in several processes, including sexual development, human-specific brain development, tumor suppression, and the cellular stress response .
GADD45G plays a crucial role in the regulation of growth and apoptosis. It mediates the activation of stress-responsive MTK1/MEKK4 MAPKKK pathways . This protein responds to environmental stresses by activating the p38/JNK pathway via MTK1/MEKK4 kinase . The activation of these pathways leads to various cellular responses, including DNA repair, cell cycle arrest, and apoptosis.
The expression of GADD45G is highly induced under stressful growth arrest conditions and treatment with DNA-damaging agents . It is highly expressed in the placenta and other tissues . The protein interacts with several other proteins involved in DNA repair, cell cycle control, apoptosis, and senescence .
Low expression of GADD45G has been associated with various types of cancer . Its role as a tumor suppressor was discovered in 1999 . The protein’s ability to mediate stress responses and regulate cell cycle arrest makes it a critical component in maintaining cellular integrity and preventing tumorigenesis.
GADD45G was originally cloned by Beadling under the name CR6 in 1993 . It was identified as an immediate early response gene in T lymphocytes induced by IL-2 . Its role as a tumor suppressor and its regulation by Oncostatin M were later discovered, leading to its current understanding as a critical stress response protein .
Research on GADD45G continues to explore its role in various cellular processes and its potential therapeutic applications. The recombinant form of this protein is used in various research studies to understand its function and mechanism in greater detail.
