FGF1 Human, 154 a.a.
Escherichia Coli.
HBGF-1, ECGF-beta, FIBP, FGFIBP, FIBP-1, ECGF, ECGFA, GLIO703, FGF1, FGF-a.
Sterile Filtered White lyophilized (freeze-dried) powder.
Greater than 97.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Description
Fibroblast Growth Factor-acidic Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 154 amino acids and having a molecular mass of 17.3kDa. The FGF1 is purified by proprietary chromatographic techniques.
Product Specs
HBGF-1, ECGF-beta, FIBP, FGFIBP, FIBP-1, ECGF, ECGFA, GLIO703, FGF1, FGF-a.
Escherichia Coli.
AEGEITTFTA LTEKFNLPPG NYKKPKLLYC SNGGHFLRIL PDGTVDGTRD RSDQHIQLQL SAESVGEVYI KSTETGQYLA MDTDGLLYGS QTPNEECLFL ERLEENHYNT YISKKHAEKN WFVGLKKNGS CKRGPRTHYG QKAILFLPLP VSSD.
Product Science Overview
Fibroblast Growth Factor-acidic (FGF-acidic), also known as FGF-1, is a member of the fibroblast growth factor family, which is involved in a wide range of biological processes including cell growth, development, and tissue repair. The human recombinant form of FGF-acidic consists of 154 amino acids and is produced using recombinant DNA technology.
FGF-acidic is a heparin-binding protein that plays a crucial role in cell proliferation, differentiation, and survival. It interacts with high-affinity transmembrane receptors, known as fibroblast growth factor receptors (FGFRs), to initiate a cascade of downstream signaling pathways. These pathways are essential for various cellular processes such as angiogenesis, wound healing, and embryonic development.
- Cell Proliferation and Differentiation: FGF-acidic is known to stimulate the proliferation of fibroblasts, endothelial cells, and other cell types. It also promotes the differentiation of stem cells into various lineages, making it a vital factor in tissue regeneration and repair.
- Angiogenesis: FGF-acidic is a potent angiogenic factor, meaning it promotes the formation of new blood vessels. This property is particularly important in wound healing and the development of new tissues.
- Neuroprotection and Neurogenesis: FGF-acidic has been shown to have neuroprotective effects and is involved in the development and maintenance of the nervous system. It supports the survival and growth of neurons and glial cells.
The human recombinant form of FGF-acidic is produced using Escherichia coli (E. coli) expression systems. The gene encoding FGF-acidic is inserted into a plasmid vector, which is then introduced into E. coli cells. These cells are cultured under specific conditions to express the FGF-acidic protein. The protein is then purified through various chromatographic techniques to achieve high purity and biological activity.
- Research: Recombinant FGF-acidic is widely used in research to study cell signaling pathways, cell proliferation, and differentiation. It is also used in the development of tissue engineering and regenerative medicine strategies.
- Therapeutics: Due to its role in promoting cell growth and tissue repair, FGF-acidic has potential therapeutic applications in wound healing, cardiovascular diseases, and neurodegenerative disorders.
- Biotechnology: FGF-acidic is used in the biotechnology industry for the production of cell culture media and other products that require the stimulation of cell growth and proliferation.
