FAM3C Human
Family with Sequence Similarity 3, Member C Human Recombinant
Cat. No.
BT7931
Source
E.coli.
Synonyms
Family with sequence similarity 3 member C, ILEI, Interleukin-like EMT inducer, predicted osteoblast protein, GS3876, protein FAM3C.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 90% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
FAM3C Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 224 amino acids (25-227) and having a molecular mass of 24.5 kDa.
FAM3C is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
FAM3C is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Introduction
FAM3C belongs to the FAM3 family and possesses a GG domain. The expression of this protein is differentially regulated in pancreatic cancer-derived cells. Serving as a downstream target gene for the Nkx5-1 transcription factor, FAM3C participates in cell differentiation and proliferation during inner ear embryogenesis. Additionally, FAM3C plays a role in retinal laminar formation and promotes the transition from epithelial to mesenchymal cells.
Description
Recombinant human FAM3C, produced in E.coli, is a single, non-glycosylated polypeptide chain. It comprises 224 amino acids (residues 25-227) and has a molecular weight of 24.5 kDa. The protein is fused to a 21 amino acid His-tag at the N-terminus and purified using proprietary chromatographic techniques.
Physical Appearance
A clear, colorless solution that is sterile filtered.
Formulation
The FAM3C solution is provided at a concentration of 0.5mg/ml and contains 20mM Tris-HCl buffer (pH 8.0), 5mM DTT, 200mM NaCl, and 20% glycerol.
Stability
For short-term storage (2-4 weeks), store the solution at 4°C. For longer storage, freeze the solution at -20°C. The addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Avoid multiple freeze-thaw cycles.
Purity
The purity of FAM3C is determined by SDS-PAGE analysis to be greater than 90%.
Synonyms
Family with sequence similarity 3 member C, ILEI, Interleukin-like EMT inducer, predicted osteoblast protein, GS3876, protein FAM3C.
Source
E.coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MQVFEIKMDA SLGNLFARSA LDTAARSTKP PRYKCGISKA CPEKHFAFKM ASGAANVVGP KICLEDNVLM SGVKNNVGRG INVALANGKT GEVLDTKYFD MWGGDVAPFI EFLKAIQDGT IVLMGTYDDG ATKLNDEARR LIADLGSTSI TNLGFRDNWV FCGGKGIKTK SPFEQHIKNN KDTNKYEGWP EVVEMEGCIP QKQD
Product Science Overview
Gene and Protein Structure
Function and Biological Role
FAM3C plays a significant role in various biological processes:
- Epithelial-Mesenchymal Transition (EMT): FAM3C is known to promote EMT, a process where epithelial cells lose their cell polarity and adhesion properties to become mesenchymal stem cells. This transition is essential for various developmental processes and has implications in cancer metastasis .
- Retinal Laminar Formation: FAM3C may be involved in the formation of retinal layers, indicating its role in eye development .
- Cytokine Activity: The protein exhibits cytokine activity, which is involved in cell signaling and immune responses .
Clinical Significance
Recombinant FAM3C
Research and Applications
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