FAM3A Human

Family with Sequence Similarity 3, Member A Human Recombinant
Cat. No.
BT7802
Source
Escherichia Coli.
Synonyms
Protein FAM3A, Cytokine-like protein 2-19, FAM3A, 2-19, 2.19, DLD, XAP-7, DXS560S.
Appearance
Filtered White lyophilized (freeze-dried) powder.
Purity
Greater than 95.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

FAM3A Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 207 amino acids including a 10 a.a N-terminal His tag. The total molecular mass is 23.1kDa (calculated).

Product Specs

Introduction
FAM3A (Family with Sequence Similarity 3, Member A) belongs to the FAM3 family alongside FAM3B (Pander). While FAM3B is known to induce apoptosis in pancreatic alpha and beta cells, FAM3A's function is less clear. This cytokine-like protein is widely expressed, found in tissues like the testis, pancreas, adrenal glands, placenta, brain (including fetal brain), liver, kidney, skeletal muscle, and heart. Evidence suggests that FAM3A gene expression may be regulated by PPAR-gamma (peroxisome proliferator-activated receptor gamma), potentially implicating FAM3A in glucose and lipid metabolism. Additionally, research suggests it might act as a defense mechanism against fungal infections.
Description
Recombinant Human FAM3A, produced in E. coli, is a single, non-glycosylated polypeptide chain. It comprises 207 amino acids, including a 10-amino acid N-terminal His-tag. The calculated molecular mass is 23.1 kDa.
Physical Appearance
White, lyophilized powder after filtration.
Formulation
The FAM3A protein solution (0.5 mg/mL in 20 mM TRIS, 50 mM NaCl, pH 7.5) is filtered through a 0.4 μm filter and then lyophilized.
Solubility
To create a working stock solution, add deionized water to the lyophilized pellet, aiming for a concentration of around 0.5 mg/mL. Allow sufficient time for the pellet to dissolve completely. Note: This product is not sterile. Filter it through a sterile filter before using it in cell culture.
Stability
Store the lyophilized protein at -20°C. After reconstitution, aliquot the protein to minimize freeze-thaw cycles. Reconstituted FAM3A can be stored at 4°C for a limited time (approximately two weeks) with no observable changes in its properties.
Purity
Purity is determined to be greater than 95.0% by SDS-PAGE analysis.
Synonyms
Protein FAM3A, Cytokine-like protein 2-19, FAM3A, 2-19, 2.19, DLD, XAP-7, DXS560S.
Source
Escherichia Coli.
Amino Acid Sequence
MKHHHHHHASFPRIQQLFTS PESSVTAAPR ARKYKCGLPQ PCPEEHLAFR VVSGAANVIG PKICLEDKML MSSVKDNVGR GLNIALVNGV SGELIEARAF DMWAGDVNDL LKFIRPLHEG TLVFVASYDD PATKMNEETR KLFSELGSRN AKELAFRDSW VFVGAKGVQN KSPFEQHVKN SKHSNKYEGW PEALEMEGCI PRRSTAS.

Product Science Overview

Structure and Function

FAM3A encodes a secreted protein with a GG domain, which is a characteristic feature of the FAM3 family. The GG domain is involved in protein-protein interactions and is essential for the protein’s function. FAM3A is known to play a role in the regulation of glucose and lipid metabolism, making it a significant protein in the context of metabolic diseases.

The protein is ubiquitously expressed in various tissues, indicating its importance in multiple physiological processes. It has been observed that changes in the expression of FAM3A can have significant implications for cellular function and overall health.

Role in Disease

Alterations in the expression of FAM3A have been linked to several diseases. For instance, it has been associated with metabolic disorders such as diabetes and obesity. The protein’s role in regulating glucose and lipid metabolism makes it a potential target for therapeutic interventions aimed at treating these conditions.

Additionally, FAM3A has been implicated in cancer biology. Changes in its expression have been noted in pancreatic cancer-derived cells, suggesting that it may play a role in tumorigenesis. Further research is needed to fully understand the mechanisms by which FAM3A contributes to cancer development and progression.

Research and Applications

Recombinant FAM3A protein is widely used in research to study its function and role in various diseases. The recombinant protein is typically produced in an expression system such as E. coli and purified to high levels of purity. This allows researchers to conduct experiments to elucidate the protein’s function, interactions, and potential as a therapeutic target.

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