EXOSC9 Human
Description
Product Specs
For short-term storage (up to 4 weeks), the product can be stored at 4°C. For long-term storage, it is recommended to store the product at -20°C. Repeated freezing and thawing should be avoided.
Product Science Overview
EXOSC9 is part of the RNA exosome core complex, which consists of nine subunits (Exo-9). This core complex is catalytically inactive but serves as a scaffold for the association with catalytic subunits and accessory proteins or complexes . The human recombinant EXOSC9 protein is typically expressed in baculovirus-insect cells and consists of 458 amino acids, predicting a molecular mass of approximately 51.3 kDa .
The primary function of EXOSC9 is to participate in the degradation of RNA molecules, including histone mRNA . It is involved in both the nucleus and cytoplasm, where it processes and degrades various RNA species. This component is essential for the binding and presentation of RNA for ribonucleolysis, ensuring the proper turnover and quality control of RNA within the cell .
EXOSC9 plays a vital role in several cellular processes, including:
- mRNA Degradation: It is involved in the degradation of messenger RNA (mRNA), which is crucial for regulating gene expression and maintaining cellular function .
- RNA Processing: EXOSC9 is part of the exosome complex that processes various RNA molecules, ensuring their proper maturation and function .
- Immune Response: It has been implicated in the innate immune response, particularly in lymphoid tissues and bone marrow .
Recombinant human EXOSC9 protein is produced using baculovirus-insect cell expression systems. The protein is typically purified to a high degree of purity (>85%) and is available in lyophilized form for research and therapeutic applications . It is essential to store the protein under sterile conditions at -20°C to -80°C to maintain its stability and activity .
