Dengue type 2 Antibody

Dengue fever is a mosquito-borne viral infection caused by the dengue virus, which belongs to the genus Flavivirus within the family Flaviviridae. There are four distinct serotypes of the dengue virus, namely DENV-1, DENV-2, DENV-3, and DENV-4. Among these, Dengue Virus Type 2 (DENV-2) is one of the most studied due to its significant impact on public health.

The envelope (E) protein of the dengue virus is a glycoprotein that plays a crucial role in the virus’s ability to infect host cells. It is involved in the processes of viral attachment, membrane fusion, and entry into the host cell. The E protein is also the primary target for neutralizing antibodies, making it a key focus for vaccine development and therapeutic interventions.

The E protein is composed of three distinct domains:

1. Domain I (DI): Central domain that forms the core of the protein.
2. Domain II (DII): Contains the fusion loop, which is critical for the fusion of the viral and host cell membranes.
3. Domain III (DIII): Involved in receptor binding and is a major target for neutralizing antibodies.

Mouse antibodies against the dengue virus type 2 envelope protein are commonly used in research to study the immune response to dengue infection and to develop diagnostic tools and vaccines. These antibodies can be monoclonal or polyclonal.

• Monoclonal Antibodies: These are produced by identical immune cells that are clones of a unique parent cell. They are highly specific to a single epitope on the antigen. Monoclonal antibodies against the DENV-2 envelope protein are used in various applications, including Western Blot, Immunocytochemistry, ELISA, Immunohistochemistry, and Flow Cytometry .
• Polyclonal Antibodies: These are produced by different immune cells and are a mixture of antibodies that recognize multiple epitopes on the antigen. Polyclonal antibodies against the DENV-2 envelope protein are also widely used in research for similar applications .

The use of mouse antibodies against the DENV-2 envelope protein has several important applications:

1. Research: These antibodies are used to study the structure and function of the E protein, as well as the immune response to dengue infection.
2. Diagnostics: They are used in diagnostic assays to detect the presence of dengue virus in clinical samples.
3. Vaccine Development: Understanding the interaction between the E protein and neutralizing antibodies is crucial for the development of effective dengue vaccines.
4. Therapeutics: These antibodies can be used to develop therapeutic agents that target the dengue virus.