DCUN1D1 Human

The DCUN1D1 gene is located on human chromosome 3 and encodes a protein that is part of the E3 ubiquitin ligase complex for neddylation . The protein promotes the neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by binding to cullin-RBX1 complexes in the cytoplasm and facilitating their nuclear translocation . This process enhances the recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex and optimizes the orientation of proteins within the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates .

DCUN1D1 is involved in several key biological pathways, including the metabolism of proteins and protein neddylation . It plays a significant role in the positive regulation of protein neddylation and the regulation of protein ubiquitination . Additionally, DCUN1D1 is part of the ubiquitin ligase complex and is located in the cytosol and nucleoplasm .

Mutations or dysregulation of the DCUN1D1 gene have been associated with various diseases, including glioma susceptibility and squamous cell carcinoma . The protein also acts as an oncogene, facilitating malignant transformation and carcinogenic progression . This makes DCUN1D1 a potential target for therapeutic interventions in cancer treatment.

Recombinant DCUN1D1 proteins are used in research to study the neddylation process and its implications in various diseases. These proteins are produced using recombinant DNA technology, which involves inserting the DCUN1D1 gene into an expression system to produce the protein in large quantities. Recombinant DCUN1D1 proteins are available in various quantities and are shipped with ice packs to maintain their stability .