CXCL17 Human, His

VEGF Co-regulated Chemokine 1, also known as CXCL17, is a small cytokine belonging to the CXC family of chemokines. It is also referred to as VEGF co-regulated chemokine 1 (VCC-1) and dendritic-cell and monocyte-attracting chemokine-like protein (DMC). Chemokines are signaling proteins secreted by cells to mediate immune responses and cellular communication. The CXC chemokines are one of the four main subfamilies of chemokines, characterized by the presence of a cysteine residue separated by one amino acid .

The recombinant form of VEGF Co-regulated Chemokine 1 is typically produced using recombinant DNA technology. This involves inserting the gene encoding the chemokine into an expression vector, which is then introduced into a host cell, such as E. coli or mammalian cells. The host cells express the protein, which is subsequently purified using affinity chromatography techniques. The His tag, a sequence of histidine residues, is often added to the protein to facilitate purification and detection .

VEGF Co-regulated Chemokine 1 plays a crucial role in various biological processes, including angiogenesis, immune cell recruitment, and inflammation. It interacts with specific receptors on the surface of target cells, triggering signaling pathways that lead to cellular responses. The chemokine’s activity is regulated by its binding to glycosaminoglycans (GAGs) on the cell surface, which modulates its interaction with receptors and enhances its stability .