COMMD9 Human
COMM Domain Containing 9 Human Recombinant
Cat. No.
BT13574
Source
E.coli.
Synonyms
COMM Domain Containing Protein 9, FLJ31106, HSPC166, COMM9.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 95% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
COMMD9 Human Recombinant produced in E. coli is a single polypeptide chain containing 221 amino acids (1-198) and having a molecular mass of 24.2 kDa. COMMD9 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Introduction
COMMD9, also known as COMM domain-containing protein 9, belongs to the COMMD family. This family consists of proteins that are evolutionarily conserved and characterized by a shared COMM domain at their C-terminus. This domain facilitates protein-protein interactions. COMMD9 is a ubiquitously expressed protein composed of 198 amino acids. It contains a single COMM domain and plays a role in various signaling pathways throughout the cell.
Description
Recombinant COMMD9 Human, produced in E. coli, is a single polypeptide chain consisting of 221 amino acids (amino acids 1-198) with a molecular weight of 24.2 kDa. A 23 amino acid His-tag is fused to the N-terminus of COMMD9. The protein is purified using proprietary chromatographic techniques.
Physical Appearance
A clear, sterile-filtered solution.
Formulation
The COMMD9 solution is provided at a concentration of 1mg/ml in a buffer consisting of 20mM Tris-HCl (pH 8.0), 0.15M NaCl, 1mM DTT, and 10% glycerol.
Stability
For short-term storage (2-4 weeks), the solution can be stored at 4°C. For extended storage, it is recommended to freeze the solution at -20°C. The addition of a carrier protein (0.1% HSA or BSA) is advised for long-term storage. Repeated freezing and thawing should be avoided.
Purity
The purity of COMMD9 is determined to be greater than 95% based on SDS-PAGE analysis.
Synonyms
COMM Domain Containing Protein 9, FLJ31106, HSPC166, COMM9.
Source
E.coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMAALTAE HFAALQSLLK ASSKDVVRQL CQESFSSSAL GLKKLLDVTC SSLSVTQEEA EELLQALHRL TRLVAFRDLS SAEAILALFP ENFHQNLKNL LTKIILEHVS TWRTEAQANQ ISLPRLVDLD WRVDIKTSSD SISRMAVPTC LLQMKIQEDP SLCGDKPSIS AVTVELSKET LDTMLDGLGR IRDQLSAVAS K.
Product Science Overview
Structure and Expression
Function
COMMD9 is involved in several cellular processes, including:
- Sodium Ion Transport: It modulates sodium ion transport in epithelial cells by regulating the apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits .
- Cholesterol Homeostasis: It plays a role in maintaining cholesterol homeostasis within the cell .
- NF-kappa-B Regulation: COMMD9 may down-regulate the activation of NF-kappa-B, a protein complex that controls the transcription of DNA, cytokine production, and cell survival .
- Cullin-RING E3 Ubiquitin Ligase (CRL) Complexes: It may modulate the activity of these complexes, which are involved in targeting proteins for degradation .
Localization
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