COMMD7 Human

COMMD7 is a 200 amino acid protein that contains a single COMM domain . This domain facilitates interactions with other proteins, including COMMD1, another member of the COMMD family . The protein is widely expressed in various tissues, with the highest expression observed in the lung .

One of the key functions of COMMD7 is its association with the NF-kappa-B complex. NF-kappa-B is a transcription factor that plays a critical role in regulating immune response, inflammation, and cell survival. COMMD7 interacts with this complex and suppresses its transcriptional activity . This suppression is essential for maintaining cellular homeostasis and preventing excessive inflammatory responses.

Recombinant human COMMD7 protein is produced using recombinant DNA technology. The protein is typically expressed in E. coli and purified using conventional chromatography techniques . The recombinant version of COMMD7 often includes a His-tag at the N-terminus, which facilitates its purification and detection .

The recombinant protein is used in various research applications, including studies on protein-protein interactions, signal transduction pathways, and the regulation of transcriptional activity. It is also valuable for investigating the role of COMMD7 in diseases where NF-kappa-B signaling is dysregulated, such as cancer and inflammatory disorders.

The ability of COMMD7 to modulate NF-kappa-B activity makes it a potential target for therapeutic interventions. By understanding how COMMD7 interacts with the NF-kappa-B complex, researchers can develop strategies to modulate this pathway in diseases characterized by chronic inflammation and immune dysregulation.

Additionally, the study of COMMD7 and its interactions with other proteins can provide insights into the broader functions of the COMMD family. This knowledge can contribute to the development of novel therapeutic approaches for a range of diseases.