CD90 Thy-1.1 Antibody
Description
Product Specs
Product Science Overview
Thy-1 was first identified in the thymus, hence the name “Thy.” The nomenclature “Thy-1.1” and “Thy-1.2” refers to different allelic forms of the Thy-1 antigen found in mice. Thy-1.1 is expressed in certain mouse strains such as AKR/J, PL, and FVB/N, while Thy-1.2 is found in other strains like C57BL/6 and BALB/c .
Thy-1 is expressed on a variety of cell types, including:
- Hematopoietic stem cells
- Neurons
- Thymocytes
- Peripheral T cells
- Fibroblasts
- Stromal cells
In the immune system, Thy-1 is involved in T cell activation and differentiation. It interacts with CD45, a protein tyrosine phosphatase, to mediate signal transduction during lymphocyte proliferation . Additionally, Thy-1 has been implicated in the regulation of cell adhesion, apoptosis, and inflammation.
The rat anti-mouse Thy-1.1 antibody is a monoclonal antibody that specifically targets the Thy-1.1 antigen in mice. This antibody is commonly used in various scientific applications, including:
- Flow Cytometry
- Immunohistochemistry
- Immunoprecipitation
- Western Blotting
- In vitro activation of leukocytes
The antibody is typically conjugated with fluorophores such as PE (phycoerythrin) or FITC (fluorescein isothiocyanate) to facilitate detection and analysis .
Thy-1.1 antibodies are valuable tools in immunological research. They are used to:
- Identify and isolate specific cell populations: For example, hematopoietic stem cells and thymocytes.
- Study cell signaling pathways: By examining the interactions between Thy-1 and other cell surface molecules.
- Investigate cellular responses: Such as apoptosis and proliferation in various experimental models.
