CD68 Human, 38kDa
CD68 Human Recombinant, 38kDa
Cat. No.
BT30377
Source
Escherichia Coli.
Synonyms
Macrosialin, Gp110, CD68 antigen, CD68, SCARD1, DKFZp686M18236.
Appearance
Sterile Filtered clear solution.
Purity
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
CD68 Human Recombinant full length expressed in E.coli, shows a 38 kDa band on SDS-PAGE.
CD68 is purified by proprietary chromatographic techniques.
CD68 is purified by proprietary chromatographic techniques.
Product Specs
Introduction
CD68 is a gene that codes for a large glycoprotein found on the surface of certain immune cells. This protein, with a weight of 110 kDa, is commonly found on monocytes and macrophages in tissues. It belongs to a family of proteins associated with lysosomes and endosomes, acting as a type I integral membrane protein. CD68 is mainly found within lysosomes and endosomes, with a small amount on the cell surface. Its outer part is heavily coated with sugar molecules and can attach to specific molecules like lectins and selectins. As part of the scavenger receptor family, CD68 helps clear cellular waste, facilitates engulfment of foreign particles, and plays a role in attracting and activating macrophages. Different versions of the CD68 protein exist due to alternative splicing of its mRNA.
Description
This product consists of the full-length human CD68 protein, with a molecular weight of 38 kDa, produced recombinantly in E. coli. The protein has been purified using proprietary chromatographic methods.
Physical Appearance
The product is a clear solution that has been sterilized through filtration.
Formulation
The product is provided as a solution of CD68 in a buffer containing 50mM Tris-Acetate, pH 7.5, 1mM EDTA, and 20% Glycerol. The concentration of CD68 is 100 µg per 1 ml.
Stability
To ensure product stability, store the vial at a temperature between -20°C and -80°C. Under these conditions, the protein remains stable for a period of 12 months. Avoid repeated freezing and thawing of the product.
Synonyms
Macrosialin, Gp110, CD68 antigen, CD68, SCARD1, DKFZp686M18236.
Source
Escherichia Coli.
Product Science Overview
Structure and Expression
Function
CD68 plays a crucial role in the immune system. It is involved in the phagocytic pathway, where it helps in the clearance of cellular debris and pathogens. This protein is highly expressed in macrophages, which are key players in the body’s defense mechanism . CD68 is also used as a marker to identify macrophages in tissue sections, making it valuable in immunohistochemistry and flow cytometry .
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