CD226 Human
Description
CD226 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
CD226 is characterized by its extracellular domain, which contains two immunoglobulin-like domains, a single transmembrane region, and a cytoplasmic tail . The extracellular domain of CD226 interacts with its ligands, CD155 (Poliovirus Receptor, PVR) and CD112 (Nectin-2), which are expressed on the surface of target cells . These interactions are critical for the activation of NK cells and T cells, leading to the release of cytotoxic granules and cytokines that help in the elimination of infected or malignant cells .
CD226 is a co-stimulatory receptor that enhances the cytotoxic activity of NK cells and T cells . Upon binding to its ligands, CD226 transmits activating signals that promote the formation of the immunological synapse, a specialized junction between the immune cell and its target . This synapse facilitates the directed secretion of cytotoxic molecules, such as perforin and granzymes, which induce apoptosis in the target cell . Additionally, CD226 signaling enhances the production of cytokines like interferon-gamma (IFN-γ), which further amplifies the immune response .
The expression and function of CD226 have been implicated in various immunological diseases and cancer . In cancer, CD226 plays a dual role by promoting the anti-tumor activity of NK cells and T cells, while also being a target for immune evasion by tumor cells . Tumor cells can downregulate the expression of CD155 and CD112, thereby reducing the effectiveness of CD226-mediated immune responses . In autoimmune diseases, aberrant CD226 signaling has been associated with the pathogenesis of conditions such as multiple sclerosis and rheumatoid arthritis .
Recombinant human CD226 is produced using human embryonic kidney (HEK293) cells . The recombinant protein is typically tagged with a histidine (His) tag to facilitate purification and detection . It is used in various research applications, including studies on immune cell activation, cell adhesion, and signal transduction . The recombinant protein is also employed in the development of therapeutic strategies targeting CD226 and its ligands for the treatment of cancer and autoimmune diseases .
