C19ORF80 Rat

Chromosome 19 Open Reading Frame 80 Rat Recombinant
Cat. No.
BT9696
Source
Escherichia Coli.
Synonyms
Betatrophin, Angiopoietin-like protein 8, Lipasin, C19orf80, Angptl8, RIFL, TD26, PRO1185, PVPA599.
Appearance
Filtered White lyophilized (freeze-dried) powder.
Purity
Greater than 95.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

C19ORF80 Rat Recombinant produced in E. coli is a polypeptide chain containing 193 amino acids and having a total molecular mass of 22.0 kDa. C19ORF80 has a N-Terminal His-tag 
(10 AA residue).

Product Specs

Introduction
Chromosome 19 Open Reading Frame 80 (C19ORF80), a member of the ANGPTL protein family, is a crucial regulator of lipid metabolism. It may regulate serum triglyceride levels by facilitating ANGPTL3 cleavage. This hormone promotes pancreatic beta cell proliferation and expansion, improving glucose tolerance. Primarily expressed in the liver, C19ORF80 is also found in adipose tissues and is upregulated in response to food intake and insulin stimulation.
Description
Recombinant C19ORF80 Rat, produced in E. coli, is a polypeptide chain comprising 193 amino acids with a molecular weight of 22.0 kDa. It includes a N-terminal His-tag (10 amino acid residues).
Physical Appearance
White lyophilized powder after filtration.
Formulation
The product is filtered (0.4 µm) and lyophilized from a 0.5 mg/ml solution containing 0.03 M Acetate buffer with a pH of 4.0.
Solubility
To prepare a working stock solution of approximately 0.5 mg/ml, add 0.1 M Acetate buffer (pH 4.0) to the lyophilized pellet and ensure complete dissolution. For higher pH values, dilute the solution to 10 µg/ml using the relevant buffer. The antigen's solubility is limited at higher concentrations. Note: C19ORF80 is not sterile. Filter the product through a sterile filter before cell culture use.
Stability
Store the lyophilized protein at -20°C. After reconstitution, aliquot and store the product to avoid repeated freeze-thaw cycles. The reconstituted protein remains stable at 4°C for a limited time and shows no changes for up to two weeks at 4°C.
Purity
Purity is greater than 95.0% as determined by SDS-PAGE analysis.
Synonyms
Betatrophin, Angiopoietin-like protein 8, Lipasin, C19orf80, Angptl8, RIFL, TD26, PRO1185, PVPA599.
Source
Escherichia Coli.
Amino Acid Sequence
MKHHHHHHAS VRPAPVAPLG GPEPAQYEEL TLLFHGALQL GQALNGVYKA TEARLTEAGR NLGLFDQALE FLGREVNQGR DATRELRTSL SEIQAEEDTL HLRAEATARS LREVARAQHA LRNSVRRLQV QLRGAWLGQA HQEFENLKDR ADKQNHLLWA LTGHVQRQQR EMAEQQQWLR QIQQRLHMAA LPA 

Product Science Overview

Expression Patterns and Tissue Distribution

C19ORF80 is expressed in multiple tissues, with notable expression in adipose tissue, liver, and muscle. Its expression is regulated by various physiological conditions, including fasting and feeding, which suggests its role in metabolic homeostasis.

Biological Functions

The primary function of C19ORF80 is to regulate lipid metabolism. It promotes the cleavage of angiopoietin-like protein 3 (ANGPTL3), which in turn regulates serum triglyceride levels . This regulation is crucial for maintaining lipid homeostasis and preventing metabolic disorders such as hypertriglyceridemia.

Mode of Action

C19ORF80 exerts its effects by interacting with ANGPTL3, a protein known to inhibit lipoprotein lipase (LPL) activity. By promoting ANGPTL3 cleavage, C19ORF80 indirectly enhances LPL activity, leading to increased triglyceride hydrolysis and reduced serum triglyceride levels.

Regulatory Mechanisms

The expression and activity of C19ORF80 are regulated by various factors, including nutritional status and hormonal signals. For instance, its expression is upregulated during fasting, which aligns with its role in lipid metabolism. Additionally, C19ORF80 is subject to post-translational modifications that modulate its activity and stability.

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