C19ORF80 Mouse
Chromosome 19 Open Reading Frame 80 Mouse Recombinant
Cat. No.
BT9622
Source
Escherichia Coli.
Synonyms
Betatrophin, Angiopoietin-like protein 8, Lipasin, Refeeding-induced fat and liver protein, Gm6484, Angptl8, Rifl, EG624219.
Appearance
Filtered White lyophilized (freeze-dried) powder.
Purity
Greater than 95.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
C19ORF80 Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (a.a 16-198) containing 193 amino acids including a 10 a.a N-terminal His tag. The total molecular mass is 21.8kDa (calculated).
Product Specs
Introduction
Chromosome 19 Open Reading Frame 80 (C19ORF80), a member of the ANGPTL protein family, is a crucial regulator of lipid metabolism. It may influence serum triglyceride levels by facilitating ANGPTL3 cleavage. This hormone plays a role in improving glucose tolerance by specifically promoting pancreatic beta cell proliferation and expansion. Primarily expressed in the liver, C19ORF80 is also found in adipose tissues. Its expression is responsive to food intake and stimulated by insulin.
Description
Recombinant C19ORF80 Mouse, produced in E. coli, is a non-glycosylated polypeptide chain consisting of amino acids 16-198 (including a 10 a.a. N-terminal His tag). This single chain protein has a calculated molecular mass of 21.8 kDa.
Physical Appearance
White powder, lyophilized after filtration.
Formulation
The protein was filtered (0.4 µm) and subsequently lyophilized from a 0.5 mg/ml solution in 30 mM acetate buffer with a pH of 4.
Solubility
To prepare a working solution, reconstitute the lyophilized pellet in 0.1 M Acetate buffer (pH 4) to an approximate concentration of 0.5 mg/ml. For use at a higher pH, dilute the solution with the relevant buffer to a concentration of 10 µg/ml. Note that the solubility of this antigen is limited at higher concentrations. This product is not sterile; filter through an appropriate sterile filter before use in cell culture.
Stability
Store the lyophilized protein at -20°C. Once reconstituted, aliquot the product to minimize freeze-thaw cycles. Reconstituted protein can be stored at 4°C for a limited period (up to two weeks) without significant degradation.
Purity
The purity is determined to be greater than 95% by SDS-PAGE analysis.
Synonyms
Betatrophin, Angiopoietin-like protein 8, Lipasin, Refeeding-induced fat and liver protein, Gm6484, Angptl8, Rifl, EG624219.
Source
Escherichia Coli.
Amino Acid Sequence
MKHHHHHHASVRPAPVAPLG GPEPAQYEEL TLLFHGALQL GQALNGVYRA TEARLTEAGH SLGLYDRALE FLGTEVRQGQ DATQELRTSL SEIQVEEDAL HLRAEATARS LGEVARAQQA LRDTVRRLQV QLRGAWLGQA HQEFETLKAR ADKQSHLLWA LTGHVQRQQR EMAEQQQWLR QIQQRLHTAA LPA.
Product Science Overview
Gene and Protein Structure
The C19orf80 gene encodes a protein that is part of the angiopoietin-like family. These proteins are known for their roles in regulating lipid metabolism and energy homeostasis. The protein structure includes several key domains that are crucial for its function, including a signal peptide, a coiled-coil domain, and a fibrinogen-like domain.
Biological Functions
ANGPTL8 plays a significant role in various biological processes, including:
- Lipid Metabolism: It is involved in the regulation of triglyceride levels in the blood. ANGPTL8 inhibits lipoprotein lipase (LPL), an enzyme responsible for breaking down triglycerides.
- Energy Homeostasis: It helps in maintaining energy balance within the body by regulating the storage and release of fats.
- Glucose Homeostasis: ANGPTL8 has been implicated in the regulation of glucose levels, making it a potential target for diabetes research.
Research and Applications
The recombinant version of C19orf80 (Mouse) is widely used in scientific research to understand its functions and potential therapeutic applications. Some key areas of research include:
- Metabolic Disorders: Studies are conducted to explore the role of ANGPTL8 in metabolic diseases such as obesity, diabetes, and hyperlipidemia.
- Cardiovascular Diseases: Research is ongoing to investigate the impact of ANGPTL8 on cardiovascular health, particularly its role in lipid metabolism and atherosclerosis.
- Therapeutic Development: The protein is being studied as a potential therapeutic target for treating metabolic and cardiovascular diseases.
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