ARL5B Human

ADP-Ribosylation Factor-Like 5B Human Recombinant
Cat. No.
BT14654
Source
Escherichia Coli.
Synonyms

ADP-ribosylation factor-like protein 5B, ADP-ribosylation factor-like protein 8, ARL5B, ARL8.

Appearance
Sterile Filtered colorless solution.
Purity
Greater than 90% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

ARL5B Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 199 amino acids (1-179 a.a.) and having a molecular mass of 22.5kDa.
ARL5B is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction
ADP-ribosylation factor-like protein 5B (ARL5B) belongs to a family of proteins structurally similar to ADP-ribosylation factors. Both ARLs and ARFs are part of the RAS superfamily of regulatory GTPases. ARL5B shares a close relationship with ARL5, exhibiting 80% sequence identity. Human ARL5B demonstrates 100% identity with mouse ARL8 and 71% identity with its Drosophila counterpart.
Description
Recombinant Human ARL5B, produced in E. coli, is a single, non-glycosylated polypeptide chain comprising 199 amino acids (1-179 a.a.). It possesses a molecular mass of 22.5 kDa. This protein includes a 20 amino acid His-tag at the N-terminus and undergoes purification using proprietary chromatographic techniques.
Physical Appearance
Clear, colorless solution, sterile-filtered.
Formulation
The ARL5B protein solution (0.5mg/ml) is supplied in a buffer containing 20mM Tris-HCl (pH 8.0), 2mM DTT, 30% glycerol, 0.1M NaCl, and 1mM EDTA.
Stability
For short-term storage (2-4 weeks), the product can be stored at 4°C. For extended storage, freeze at -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Avoid repeated freeze-thaw cycles.
Purity
Purity exceeds 90% as determined by SDS-PAGE analysis.
Synonyms

ADP-ribosylation factor-like protein 5B, ADP-ribosylation factor-like protein 8, ARL5B, ARL8.

Source
Escherichia Coli.
Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGLIFAKLWS LFCNQEHKVI IVGLDNAGKT TILYQFLMNE VVHTSPTIGS NVEEIVVKNT HFLMWDIGGQ ESLRSSWNTY YSNTEFIILV VDSIDRERLA ITKEELYRML AHEDLRKAAV LIFANKQDMK GCMTAAEISK YLTLSSIKDH PWHIQSCCAL
TGEGLCQGLE WMTSRIGVR.

Product Science Overview

Structure and Function

ARL5B, like other members of the ARF family, is structurally similar to ADP-ribosylation factors. These proteins are involved in various cellular processes, including vesicular trafficking and actin cytoskeleton remodeling . ARL5B specifically binds and exchanges GTP and GDP, playing a crucial role in intracellular signaling pathways .

Genetic Information

The ARL5B gene is located on chromosome 10 in humans and is a protein-coding gene. It has several aliases, including ARL8 and ADP-Ribosylation Factor-Like Protein 8 . The gene is associated with pathways such as the Nuclear receptors meta-pathway and the Glucocorticoid receptor pathway .

Clinical Significance

Mutations or dysregulation of the ARL5B gene have been linked to certain diseases, including Left Ventricular Noncompaction . This highlights the importance of ARL5B in maintaining normal cellular functions and its potential role in disease mechanisms.

Research and Applications

Human recombinant ARL5B is used in various research applications to study its function and role in cellular processes. Understanding the mechanisms of ARL5B can provide insights into its involvement in diseases and potential therapeutic targets.

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