AGR2 Human
Description
AGR2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 191 amino acids (21-175 a.a.) and having a molecular mass of 21.9 kDa. AGR2 protein is fused to a 36 amino acid His-Tag at N-terminus and purified by standard chromatography.
Product Specs
Product Science Overview
AGR2 was originally discovered in the African clawed frog, Xenopus laevis, where it was identified as a secreted protein involved in the differentiation of the cement gland . The human homolog of this protein, AGR2, shares similar functions and has been extensively studied for its role in human physiology and pathology.
AGR2 is a small protein that is widely expressed in human tissues, particularly in those that secrete mucus or function as endocrine organs. These tissues include the lungs, stomach, colon, prostate, and small intestine . The protein’s expression is regulated by both androgens and estrogens, highlighting its importance in hormone-responsive tissues .
AGR2 has several critical functions:
- Protein Folding: As a member of the PDI family, AGR2 assists in the proper folding of proteins within the endoplasmic reticulum (ER). It helps in the formation of disulfide bonds, which are crucial for the stability and function of many proteins.
- Mucus Production: AGR2 is essential for the post-transcriptional synthesis and secretion of MUC2, a major component of mucus. This function is vital for maintaining the protective mucus barrier in the gastrointestinal tract .
- Cell Migration and Adhesion: AGR2 promotes cell adhesion and migration, processes that are important for tissue repair and regeneration .
- Cancer Progression: AGR2 has been implicated in cancer biology. High levels of AGR2 expression are associated with the downregulation of the p53 response, cell migration, and transformation in cancer cell lines . It may serve as a molecular marker and potential therapeutic target for hormone-responsive breast tumors .
