ACP1 Human
Description
Product Specs
Product Science Overview
ACP1 hydrolyzes protein tyrosine phosphate to protein tyrosine and orthophosphate. It plays a crucial role in various cellular processes, including cell proliferation, differentiation, and signal transduction. The enzyme is involved in the dephosphorylation of tyrosine residues in proteins, which is a key regulatory mechanism in cellular signaling pathways .
ACP1 is expressed in various tissues, including lymphoid tissue, bone marrow, testis, and skeletal muscle. It is involved in several biological processes such as immune response, protein ubiquitination, and transmembrane transport . The enzyme is localized in the cytoplasm and is known to interact with several other proteins, contributing to its diverse functional roles.
The activity of acid phosphatases, including ACP1, has been studied in the context of various diseases. For instance, different forms of acid phosphatase are used to evaluate the success of surgical treatment for prostate cancer . In the past, they were also used to diagnose this type of cancer. Additionally, ACP1 has been investigated as a cytogenetic marker to distinguish between different lineages of acute lymphoblastic leukemia (ALL). B-ALL (a leukemia of B lymphocytes) is acid-phosphatase negative, while T-ALL (originating from T lymphocytes) is acid-phosphatase positive .
Recombinant human ACP1 is produced using various expression systems, including bacterial, yeast, and mammalian cells. The recombinant production of ACP1 allows for the study of its structure, function, and potential therapeutic applications. The availability of recombinant ACP1 has facilitated research into its role in cellular processes and its potential as a target for drug development.
ACP1 is widely used in biochemical research to study its enzymatic activity, substrate specificity, and regulatory mechanisms. It is also used in the development of assays to measure phosphatase activity in various biological samples. The enzyme’s role in signal transduction pathways makes it a valuable tool for investigating cellular responses to different stimuli.
