ACP1 Antibody

ACP1 is a cytosolic enzyme that dephosphorylates tyrosine residues on target proteins. This dephosphorylation is essential for regulating various signaling pathways. Tyrosine phosphorylation of ACP1 increases its activity significantly, enhancing its ability to dephosphorylate targets such as the PDGF receptor . Overexpression of ACP1 in cancer cells has been linked to higher proliferative rates and larger tumor sizes .

Antibodies targeting Acid Phosphatase-1 are widely used in scientific research. These antibodies can detect ACP1 in various species, including humans, mice, and rats . They are utilized in several applications, such as Western Blot, Immunohistochemistry, ELISA, Immunoprecipitation, and Immunocytochemistry . These applications help researchers study the expression and function of ACP1 in different biological contexts.

ACP1 is involved in the regulation of the innate immune system through its role in toll-like receptor (TLR) signaling . TLRs are pattern recognition receptors that play a critical role in the body’s defense against pathogens. Dysregulation of TLR signaling can lead to various diseases, including autoimmune, inflammatory, and neurodegenerative disorders . Understanding the role of ACP1 in TLR signaling can provide insights into potential therapeutic targets for these conditions.