ACOT11 Human

ACOT11 is involved in the regulation of intracellular levels of acyl-CoA and free fatty acids, which are essential for various metabolic processes. By maintaining the balance between these molecules, ACOT11 helps regulate energy production, lipid synthesis, and degradation . This enzyme is particularly important in tissues with high metabolic activity, such as the liver, where it contributes to fatty acid oxidation and ketogenesis .

ACOT11 belongs to the type II acyl-CoA thioesterase family, which is characterized by the “hot dog” fold structure . This structural motif is crucial for the enzyme’s catalytic activity. The enzyme’s active site binds to acyl-CoA substrates, facilitating the hydrolysis reaction that releases free fatty acids and CoASH .

Human recombinant ACOT11 is produced using recombinant DNA technology, which involves inserting the human ACOT11 gene into a suitable expression system, such as Escherichia coli . This allows for the large-scale production of the enzyme for research and therapeutic purposes. Recombinant ACOT11 retains the same biochemical properties and functions as the naturally occurring enzyme, making it a valuable tool for studying lipid metabolism and developing potential treatments for metabolic disorders .

Research on ACOT11 has expanded our understanding of lipid metabolism and its role in various physiological and pathological conditions. Studies have shown that ACOT11 is involved in the regulation of lipid homeostasis, energy metabolism, and cellular signaling . Dysregulation of ACOT11 activity has been linked to metabolic disorders such as obesity, diabetes, and cardiovascular diseases .

In addition to its physiological roles, ACOT11 is also being explored as a potential therapeutic target. Modulating ACOT11 activity could provide new strategies for treating metabolic diseases by altering lipid metabolism and improving energy balance .