YWHAG Antibody

The Tyr-3/Trp-5 Monooxygenase Activation Protein Gamma, also known as YWHAH, is a crucial protein involved in various cellular processes. This protein is part of the 14-3-3 family, which is known for its role in signal transduction by binding to phosphoserine-containing proteins. The “Mouse Anti Human” designation indicates that this specific antibody is produced in mice and is designed to target the human version of the protein.

The 14-3-3 proteins, including the gamma isoform, are highly conserved across species. They typically function as dimers and are involved in a wide range of cellular processes, including apoptosis, cell cycle control, and signal transduction. The gamma isoform, in particular, has been implicated in the regulation of enzymes such as tyrosine 3-monooxygenase and tryptophan 5-monooxygenase, which are critical for neurotransmitter synthesis.

The Tyr-3/Trp-5 Monooxygenase Activation Protein Gamma is expressed in various tissues, including the brain, where it plays a significant role in neurotransmitter regulation. Its ability to bind to a wide range of phosphorylated proteins makes it a versatile player in cellular signaling pathways. This protein is also involved in the regulation of cell growth and differentiation, making it a key component in maintaining cellular homeostasis.

The primary mode of action of the Tyr-3/Trp-5 Monooxygenase Activation Protein Gamma involves binding to phosphorylated serine/threonine residues on target proteins. This binding can alter the function, localization, and stability of the target proteins, thereby modulating various signaling pathways. For example, its interaction with tyrosine 3-monooxygenase and tryptophan 5-monooxygenase is essential for the synthesis of catecholamines and serotonin, respectively.

The activity of the Tyr-3/Trp-5 Monooxygenase Activation Protein Gamma is regulated through various mechanisms, including phosphorylation and protein-protein interactions. Phosphorylation of the 14-3-3 protein itself can modulate its binding affinity for target proteins. Additionally, interactions with other proteins can either enhance or inhibit its activity, thereby fine-tuning cellular responses to various stimuli.

The Mouse Anti Human Tyr-3/Trp-5 Monooxygenase Activation Protein Gamma antibody is widely used in research to study the role of this protein in various cellular processes. It is particularly useful in immunohistochemistry, Western blotting, and immunoprecipitation assays. Researchers use this antibody to investigate the protein’s involvement in diseases such as cancer, neurodegenerative disorders, and metabolic syndromes.