VCAM1 Mouse

Vascular Cell Adhesion Molecule 1 (VCAM-1), also known as CD106, is a protein that plays a crucial role in the adhesion of leukocytes to the vascular endothelium. It is a member of the immunoglobulin superfamily and is encoded by the VCAM1 gene. In mice, the VCAM1 gene is located on chromosome 3.

VCAM-1 is a type I membrane protein that contains six or seven immunoglobulin domains. It is expressed on both large and small blood vessels, but only after the endothelial cells are stimulated by cytokines. The gene product is a cell surface sialoglycoprotein, and it is alternatively spliced into two known RNA transcripts that encode different isoforms in humans .

The primary function of VCAM-1 is to mediate the adhesion of lymphocytes, monocytes, eosinophils, and basophils to the vascular endothelium. It also plays a role in leukocyte-endothelial cell signal transduction. VCAM-1 is upregulated in response to inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α) and interleukin-1 (IL-1), which increase gene transcription and stabilize messenger RNA (mRNA) .

VCAM-1 is implicated in various inflammatory diseases, including atherosclerosis and rheumatoid arthritis. It is also involved in the development of macular fibrosis in neovascular age-related macular degeneration (nAMD). In nAMD, VCAM-1 contributes to the development of macular fibrosis by modulating macrophage functions, including migration and profibrotic polarization .

Recombinant VCAM-1 (Mouse) is produced using recombinant DNA technology, which involves inserting the VCAM1 gene into an expression system to produce the protein in vitro. This recombinant protein is used in various research applications, including studies on cell adhesion, inflammation, and signal transduction.