VAMP5 Human
Description
VAMP5 is fused to 37 amino acids His Tag at N-terminus and purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
Vesicle-associated membrane protein 5 (VAMP5), also known as myobrevin, is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family and the SNARE superfamily. These proteins play a crucial role in the docking and fusion of vesicles with cell membranes, which is essential for various cellular processes, including neurotransmitter release and hormone secretion .
The VAMP5 gene is located on chromosome 2 at the p11.2 locus. It encodes a protein that is involved in vesicle trafficking events associated with myogenesis, such as myoblast fusion and GLUT4 trafficking . The protein consists of a single transmembrane domain, a cytoplasmic domain, and a vesicle-associated domain, which are characteristic features of the VAMP family .
VAMP5 is primarily involved in the trafficking of vesicles within cells. It is a key component of the SNARE complex, which mediates the fusion of vesicles with target membranes. This process is vital for the proper functioning of various cellular activities, including the release of neurotransmitters at synapses and the secretion of hormones .
In the context of myogenesis, VAMP5 plays a significant role in the fusion of myoblasts to form multinucleated muscle fibers. This is a critical step in muscle development and regeneration. Additionally, VAMP5 is involved in the trafficking of GLUT4, a glucose transporter, to the plasma membrane in response to insulin signaling .
Mutations or dysregulation of the VAMP5 gene have been associated with various diseases. For instance, VAMP5 has been linked to infant botulism and nephronophthisis 2 . Understanding the role of VAMP5 in these conditions can provide insights into potential therapeutic targets for treating these diseases.
