UBL5 Human

Ubiquitin-Like 5 Human Recombinant
Cat. No.
BT22798
Source
Escherichia Coli.
Synonyms
Ubiquitin-like protein 5, HUB1, FLJ46917, MGC131795.
Appearance
Sterile Filtered clear solution.
Purity
Greater than 90.0% as determined by SDS-PAGE.
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Shipped with Ice Packs
In Stock

Description

UBL5 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 93 amino acids (1-73a.a) and having a molecular mass of 10.7kDa.
UBL3 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction
UBL5, unlike ubiquitin which degrades proteins, is thought to be a reversible modulator of protein function. It influences a crucial nuclear phase that enhances the response to the threat of mitochondrial protein misfolding.
Description
Recombinant Human UBL5, produced in E. coli, is a single, non-glycosylated polypeptide chain consisting of 93 amino acids (1-73a.a) and has a molecular mass of 10.7 kDa. This UBL3 protein is fused to a 20 amino acid His-tag at the N-terminus and purified using proprietary chromatographic techniques.
Physical Appearance
A clear, sterile filtered solution.
Formulation
UBL5 protein solution at a concentration of 1mg/ml, in a buffer of 20mM Tris-HCl (pH 8.0), 20% glycerol, 0.1M NaCl, and 2mM DTT.
Stability
While UBL5 can remain stable at 4°C for up to one week, it is recommended to store it below -18°C for long-term storage. It is important to avoid repeated freeze-thaw cycles.
Purity
Purity levels are greater than 90.0% as determined by SDS-PAGE analysis.
Synonyms
Ubiquitin-like protein 5, HUB1, FLJ46917, MGC131795.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MIEVVCNDRL GKKVRVKCNT DDTIGDLKKL IAAQTGTRWN KIVLKKWYTI FKDHVSLGDY EIHDGMNLEL YYQ

Product Science Overview

Structure and Expression

UBL5 is a small protein consisting of 73 amino acids. It is expressed in various species, including humans, and is highly conserved across different organisms. The recombinant form of UBL5 is often produced in Escherichia coli and purified using conventional chromatography techniques .

Function

UBL5 is involved in a nuclear step required for mounting a response to mitochondrial protein misfolding. This function is essential for maintaining cellular homeostasis and preventing the accumulation of misfolded proteins, which can lead to cellular stress and disease .

Applications

Recombinant UBL5 is used extensively in research to study its role in cellular processes and its potential therapeutic applications. It is often tagged with a His-tag at the N-terminus to facilitate purification and detection in experimental settings .

Storage and Handling

Recombinant UBL5 is typically stored at 4°C for short-term use and at -20°C for long-term storage. It is important to avoid freeze-thaw cycles to maintain the protein’s stability and functionality .

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