UBE2V2 Human
Description
Product Specs
MGSSHHHHHH SSGLVPRGSH MAVSTGVKVP RNFRLLEELE EGQKGVGDGT VSWGLEDDED MTLTRWTGMI IGPPRTNYEN RIYSLKVECG PKYPEAPPSV RFVTKINMNG INNSSGMVDA RSIPVLAKWQ NSYSIKVVLQ ELRRLMMSKE NMKLPQPPEG QTYNN.
Product Science Overview
Ubiquitin-Conjugating Enzyme E2 Variant 2 (UBE2V2) is a crucial component of the ubiquitin-proteasome system (UPS), which is responsible for the regulation of protein degradation in eukaryotic cells. This enzyme plays a significant role in various cellular processes, including DNA repair, cell cycle regulation, and signal transduction.
UBE2V2, also known as UEV2, is a member of the E2 ubiquitin-conjugating enzyme family. Unlike other E2 enzymes, UBE2V2 does not have ubiquitin ligase activity on its own. Instead, it forms a heterodimer with UBE2N (Ubc13), another E2 enzyme. This heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through lysine 63 (Lys-63). These Lys-63-linked poly-ubiquitin chains do not target proteins for degradation by the proteasome but are involved in signaling pathways, such as DNA damage response and NF-κB activation .
The UBE2V2/UBE2N heterodimer is essential for various cellular functions. It mediates the transcriptional activation of target genes and plays a critical role in the DNA damage response. The formation of Lys-63-linked poly-ubiquitin chains by UBE2V2/UBE2N is crucial for the recruitment of DNA repair proteins to sites of damage, thereby facilitating the repair process .
Mutations or dysregulation of UBE2V2 have been implicated in several diseases, including cancer and neurodegenerative disorders. For instance, alterations in the ubiquitination process can lead to the accumulation of damaged or misfolded proteins, contributing to the pathogenesis of these diseases. Understanding the role of UBE2V2 in these processes can provide insights into potential therapeutic targets for treating such conditions .
Recombinant human UBE2V2 is widely used in research to study its function and interactions with other proteins. By using recombinant proteins, researchers can investigate the molecular mechanisms underlying ubiquitination and its role in various cellular processes. Additionally, recombinant UBE2V2 can be utilized in drug discovery efforts to identify compounds that modulate its activity, offering potential therapeutic benefits .
