TPD52L1 Human

Tumor Protein D52 L1 Human Recombinant
Cat. No.
BT26182
Source
Escherichia Coli.
Synonyms
Tumor protein D53, Tumor protein D52-like 1, TPD52L1, hD53, D53, MGC8556, TPD52L2.
Appearance
Sterile filtered colorless solution.
Purity
Greater than 90.0% as determined by SDS-PAGE.
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

TPD52L1 Human Recombinant His-Tag fusion protein produced in E.Coli is a single, non-glycosylated polypeptide chain (21-151 a.a) containing amino acids 151 and having a molecular mass of 16.8 kDa.
TPD52L1 is purified by proprietary chromatographic techniques.

Product Specs

Introduction
TPD52L1 (hD53, hD53L1), a member of the D52 gene family, exhibits overexpression in human breast carcinoma. This protein features a coiled-coil motif, facilitating homo- and heteromeric interactions, and potentially regulating cell proliferation and calcium-dependent signal transduction. Notably, TPD52L1 interacts with MAP3K5/ASK1 (mitogen-activated protein kinase kinase kinase 5) and exerts a positive regulatory effect on MAP3K5-induced apoptosis.
Description
Recombinant human TPD52L1 protein, expressed in E. coli with a His-Tag fusion, is a single, non-glycosylated polypeptide chain encompassing amino acids 21-151. With a molecular weight of 16.8 kDa, this protein is purified using proprietary chromatographic techniques.
Physical Appearance
A clear, colorless solution, sterile-filtered.
Formulation
The TPD52L1 protein is supplied as a 1 mg/ml solution in 1xPBS at pH 7.4.
Stability
For short-term storage (2-4 weeks), maintain the product at 4°C. For extended storage, freeze at -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Avoid repeated freeze-thaw cycles.
Purity
Purity exceeds 90.0% as determined by SDS-PAGE analysis.
Synonyms
Tumor protein D53, Tumor protein D52-like 1, TPD52L1, hD53, D53, MGC8556, TPD52L2.
Source
Escherichia Coli.
Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MEAQAQGLLE TEPLQGTDED AVASADFSSM LSEEEKEELK AELVQLEDEI TTLRQVLSAK ERHLVEIKQK LGMNLMNELK QNFSKSWHDM QTTTAYKKTH ETLSHAGQKA TAAFSNVGTA ISKKFGDMRR K.

Product Science Overview

Discovery and Structure

The TPD52 family was initially identified through studies focused on cancer cells, where these proteins were found to be overexpressed. TPD52L1, in particular, has been studied for its involvement in various types of cancers, including breast, prostate, and ovarian cancers. The protein is composed of approximately 180 amino acids and has a molecular weight of around 28 kDa .

Function and Mechanism

TPD52L1 is involved in several cellular functions:

  • Cell Proliferation: It promotes cell division and growth, which is a critical factor in cancer progression.
  • Apoptosis: TPD52L1 can influence programmed cell death, thereby affecting tumor growth and survival.
  • Vesicle Trafficking: The protein plays a role in the transport of vesicles within the cell, which is essential for maintaining cellular homeostasis.
Recombinant Production

Recombinant Human Tumor Protein D52 L1 is produced using recombinant DNA technology. This involves inserting the gene encoding TPD52L1 into an expression system, such as bacteria or yeast, to produce the protein in large quantities. The recombinant protein is then purified for use in research and therapeutic applications .

Applications in Research and Medicine

The recombinant form of TPD52L1 is widely used in scientific research to study its role in cancer and other diseases. It is also utilized in drug development to identify potential therapeutic targets. Additionally, TPD52L1 can be used in diagnostic assays to detect its expression levels in various cancer types .

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THE BIOTEK
THE BioTek is a global biotech company offering highly purified proteins for research in cancer, apoptosis, development, endocrinology, immunology, neuroscience, proteases, and stem cells.
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