TP53I3 Human
Description
TP53I3 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 352 amino acids (1-332 a.a.) and having a molecular mass of 37.6 kDa. TP53I3 protein is fused to a 20 amino acid His tag at N-terminus and is purified by standard chromatography.
Product Specs
MGSSHHHHHH SSGLVPRGSH MLAVHFDKPG GPENLYVKEV AKPSPGEGEV LLKVAASALN RADLMQRQGQ YDPPPGASNI LGLEASGHVAELGPGCQGHW KIGDTAMALL PGGGQAQYVT VPEGLLMPIP EGLTLTQAAA IPEAWLTAFQ LLHLVGNVQA GDYVLIHAGL SGVGTAAIQLTRMAGAIPLV TAGSQKKLQM AEKLGAAAGF NYKKEDFSEA TLKFTKGAGV NLILDCIGGS YWEKNVNCLA LDGRWVLYGL MGGGDINGPLFSKLLFKRGS LITSLLRSRD NKYKQMLVNA FTEQILPHFS TEGPQRLLPV LDRIYPVTEI QEAHKYMEAN KNIGKIVLEL PQ.
Product Science Overview
TP53I3 is similar to oxidoreductases, enzymes that play a role in cellular responses to oxidative stress and irradiation . The protein is involved in p53-mediated cell death, which is a critical mechanism for preventing the proliferation of cells with damaged DNA . When cells are exposed to genotoxic agents, TP53I3 is localized to the cytoplasm and is induced in both primary and transformed cell cultures .
The TP53 gene, which encodes the p53 protein, is mutated in approximately half of all human cancers . Mutations in this gene often lead to the loss of p53’s tumor-suppressing functions, resulting in uncontrolled cell proliferation and tumor development . TP53I3, being a downstream target of p53, is also implicated in these processes. The protein’s role in oxidative stress response and apoptosis makes it a significant player in the cellular mechanisms that prevent cancer progression .
Given its involvement in p53-mediated pathways, TP53I3 is a subject of interest in cancer research. Understanding its function and regulation could lead to new therapeutic strategies aimed at restoring p53’s tumor-suppressing activities in cancers where TP53 is mutated . Additionally, TP53I3’s role in oxidative stress response suggests potential applications in therapies targeting cellular redox balance .
