TP53I3 Antibody
Description
Product Specs
Product Science Overview
Tumor Protein p53 Inducible Protein 3 (TP53I3), also known as PIG3 (p53 Inducible Gene 3), is a protein encoded by the TP53I3 gene in humans. This protein is part of the p53 signaling pathway, which plays a crucial role in regulating the cell cycle and preventing tumor formation. The p53 protein, often referred to as the “guardian of the genome,” is a transcription factor that responds to various cellular stress signals by activating genes involved in DNA repair, cell cycle arrest, and apoptosis .
TP53I3 is a member of the quinone oxidoreductase family and is involved in the cellular response to oxidative stress. The protein is induced by p53 in response to DNA damage and other stress signals. It is believed to contribute to the pro-apoptotic functions of p53 by generating reactive oxygen species (ROS), which can lead to cell death in damaged cells .
The TP53I3 gene is one of the many target genes activated by p53. Mutations in the TP53 gene, which encodes the p53 protein, are found in approximately half of all human cancers. These mutations often result in the loss of p53’s tumor-suppressing functions, leading to uncontrolled cell proliferation and tumor development . The induction of TP53I3 by p53 is part of the cellular defense mechanism against cancer, as it promotes apoptosis in cells with damaged DNA .
Mouse anti-human TP53I3 antibodies are monoclonal antibodies derived from the hybridization of mouse myeloma cells with spleen cells from immunized mice. These antibodies are used in various research applications to study the expression and function of TP53I3 in human cells. They are valuable tools for investigating the role of TP53I3 in the p53 signaling pathway and its involvement in cancer biology .
The use of mouse anti-human TP53I3 antibodies has several applications in scientific research:
- Western Blotting: To detect and quantify TP53I3 protein levels in cell and tissue samples.
- Immunohistochemistry: To visualize the localization of TP53I3 in tissue sections.
- Flow Cytometry: To analyze the expression of TP53I3 in different cell populations.
- Functional Studies: To investigate the role of TP53I3 in apoptosis and other cellular processes.
