TGF b Antibody

Transforming Growth Factor-beta, Mouse-Anti Human
Cat. No.
BT10001
Source
Synonyms
Transforming Growth Factor-beta3, TGFB3, ARVD, FLJ16571, TGF-beta3.
Appearance
Purity
Usage
Prospec's products are furnished for LABORATORY ESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

Product Specs

Introduction
Transforming growth factor betas (TGF-betas) are crucial in embryonic development, mediating cell-to-cell interactions. Mammals possess three TGF-beta isoforms: TGF-beta1, TGF-beta2, and TGF-beta3. Each isoform is synthesized as a precursor protein that undergoes cleavage to produce a 112-amino acid polypeptide. This polypeptide remains linked to the latent part of the molecule. This particular antibody exhibits reactivity towards both the precursor and mature forms of TGF-beta2, and to a lesser degree, TGF-beta3. However, it does not demonstrate cross-reactivity with TGF-beta1.
Formulation
The antibody is provided at a concentration of 1 mg/ml in phosphate-buffered saline (PBS) upon reconstitution.
Shipping Conditions
The antibody is shipped in a lyophilized form at ambient temperature.
Storage Procedures
For storage, keep the lyophilized antibody at 4°C. Once reconstituted, if not utilized within one month, aliquot the antibody and store it at -20°C.
Solubility
To reconstitute the antibody, add 0.5 ml of H2O. Mix the solution gently, ensuring to wash the sides of the vial, and allow it to sit for 30-60 seconds before use.
Note
This antibody displays strong binding affinity for protein A in a PBS buffer with a high salt concentration (3M NaCl).
Titer
In a direct ELISA setup employing alkaline phosphatase-conjugated goat anti-mouse immunoglobulin G (Jackson ImmunoResearch Laboratories) at a dilution of 1:10,000, this antibody yields an optical density (OD) of 0.7 within 10 minutes.
Synonyms
Transforming Growth Factor-beta3, TGFB3, ARVD, FLJ16571, TGF-beta3.
Purification Method
Ion exchange column.
Type
Mouse Anti Human Monoclonal.
Clone
hTGF-b.
Immunogen
r.Human TGF-b.
Ig Subclass
Mouse IgG1.

Product Science Overview

Mouse-Anti Human TGF-β Antibodies

Mouse-anti human TGF-β antibodies are monoclonal antibodies developed in mice that specifically target human TGF-β. These antibodies are used in research and therapeutic applications to neutralize the activity of TGF-β and study its role in various biological processes and diseases . For example, the mouse monoclonal pan-TGF-β neutralizing antibody 1D11 has been shown to inhibit the TGF-β pathway in human basal cell-like breast carcinoma cells .

Applications in Research and Therapy

Mouse-anti human TGF-β antibodies are valuable tools in studying the TGF-β signaling pathway and its involvement in disease progression. They are used to investigate the effects of TGF-β inhibition on cell growth, differentiation, and immune responses . Additionally, these antibodies have therapeutic potential in treating diseases associated with dysregulated TGF-β signaling, such as cancer and fibrosis .

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