TBC1D13 Human
TBC1 Domain Family, Member 13 Human Recombinant
Cat. No.
BT11006
Source
Escherichia Coli.
Synonyms
RP11-545E17.5, TBC1 domain family member 13, Tumor Suppressor Candidate 2, TBC1D13.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 95.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Shipped with Ice Packs 
In Stock 
Description
TBC1D13 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 423 amino acids (1-400) and having a molecular mass of 48.9 kDa.
TBC1D13 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
TBC1D13 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Introduction
TBC1 Domain Family, Member 13, also known as TBC1D13, is a protein that contains a Rab-GAP TBC domain. It functions as a GTPase-activating protein for the Rab family of proteins.
Description
Recombinant human TBC1D13 protein was produced in E. coli. This protein is a single, non-glycosylated polypeptide chain consisting of 423 amino acids (residues 1-400) and has a molecular weight of 48.9 kDa. The TBC1D13 protein has a 23 amino acid His-tag fused at the N-terminus and is purified using proprietary chromatographic techniques.
Physical Appearance
Clear, colorless, and sterile-filtered solution.
Formulation
The TBC1D13 solution is provided at a concentration of 1 mg/ml and contains 20 mM Tris-HCl buffer (pH 8.0), 0.15 M NaCl, 10% glycerol, and 1 mM DTT.
Stability
For short-term storage (up to 2-4 weeks), the TBC1D13 solution should be stored at 4°C. For long-term storage, it is recommended to store the protein at -20°C. Adding a carrier protein such as 0.1% HSA or BSA is recommended for long-term storage. Repeated freezing and thawing of the protein should be avoided.
Purity
The purity of the TBC1D13 protein is greater than 95% as determined by SDS-PAGE analysis.
Synonyms
RP11-545E17.5, TBC1 domain family member 13, Tumor Suppressor Candidate 2, TBC1D13.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMSSLHKS RIADFQDVLK EPSIALEKLR ELSFSGIPCE GGLRCLCWKI LLNYLPLERA SWTSILAKQR ELYAQFLREM IIQPGIAKAN MGVSREDVTF EDHPLNPNPD SRWNTYFKDN EVLLQIDKDV RRLCPDISFF QRATDYPCLL ILDPQNEFET LRKRVEQTTL KSQTVARNRS GVTNMSSPHK NSVPSSLNEY EVLPNGCEAH WEVVERILFI YAKLNPGIAY VQGMNEIVGP LYYTFATDPN SEWKEHAEAD TFFCFTNLMA EIRDNFIKSL DDSQCGITYK MEKVYSTLKD KDVELYLKLQ EQNIKPQFFA FRWLTLLLSQ EFLLPDVIRI WDSLFADDNR FDFLLLVCCA MLMLIREQLL EGDFTVNMRL LQDYPITDVC QILQKAKELQ DSK.
Product Science Overview
Gene and Protein Information
- Gene Symbol: TBC1D13
- Protein Name: TBC1 Domain Family Member 13
- Aliases: FLJ10743, Epididymis Secretory Sperm Binding Protein 3
- UniProt ID: Q9NVG8
- NCBI Gene ID: 54662
Function
TBC1D13 acts as a GTPase-activating protein (GAP) for Rab family proteins, specifically RAB35 . GTPase-activating proteins are crucial for the regulation of GTPases, which are involved in various cellular processes such as vesicle-mediated transport and intracellular protein trafficking . TBC1D13, in conjunction with RAB35, is implicated in the regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes .
Pathways and Interactions
Clinical Significance
Recombinant Protein
The recombinant form of TBC1D13 is produced in E. coli and is a single, non-glycosylated polypeptide chain containing 423 amino acids with a molecular mass of approximately 48.9 kDa . This recombinant protein is often used in research to study the function and interactions of TBC1D13 in various cellular processes .
Research Applications
Quick Inquiry
Personal Email Detected
Please use an institutional or corporate email address for inquiries. Personal email accounts ( such as Gmail, Yahoo, and Outlook) are not accepted. *
