SULT2A1 Antibody
Sulfotransferase family cytosolic 2A dehydroepiandrosterone (DHEA)-preferring member 1, DHEA-ST, STD, HST, ST2, ST2A1, ST2A3, Alcohol/hydroxysteroid sulfotransferase, bile-salt sulfotranasferase 2A1, EC 2.8.2.14.
Description
Product Specs
Sulfotransferase family cytosolic 2A dehydroepiandrosterone (DHEA)-preferring member 1, DHEA-ST, STD, HST, ST2, ST2A1, ST2A3, Alcohol/hydroxysteroid sulfotransferase, bile-salt sulfotranasferase 2A1, EC 2.8.2.14.
SULT2A1 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
PAT13E10AT.
Anti-human SULT2A1 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human SULT2A1 amino acids 1-285 purified from E. coli.
Mouse IgG2a heavy chain and κ light chain.
Product Science Overview
The Sulfotransferase Family, Cytosolic, 2A, Member 1 (SULT2A1) is a crucial enzyme involved in the metabolism of various endogenous and exogenous compounds. This enzyme is part of the larger sulfotransferase (SULT) family, which plays a significant role in the sulfonation process, aiding in the detoxification and excretion of numerous substances.
SULT2A1 is a protein-coding gene that encodes for the enzyme responsible for the sulfonation of steroids and bile acids. The gene is located on chromosome 19 in humans and has several aliases, including DHEA-ST, STD, and HST . The enzyme utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as a sulfonate donor to catalyze the sulfonation process .
The primary function of SULT2A1 is to catalyze the sulfonation of a wide range of steroids and sterols, including pregnenolone, androsterone, dehydroepiandrosterone (DHEA), bile acids, and cholesterol . This process increases the water solubility of these compounds, facilitating their renal excretion. Additionally, SULT2A1 can sulfonate various xenobiotics containing alcohol and phenol functional groups .
SULT2A1 is predominantly expressed in the liver and adrenal glands, where it plays a vital role in steroid metabolism and bile acid regulation . The enzyme’s activity is crucial for maintaining hormonal balance and detoxifying potentially harmful substances. In women with polycystic ovary syndrome (PCOS), SULT2A1 may contribute to inherited adrenal androgen excess .
Research on SULT2A1 has expanded our understanding of its role in chemical metabolism and detoxification. Studies have shown that the enzyme’s activity can be influenced by genetic polymorphisms, which may affect an individual’s response to drugs and environmental toxins . Additionally, SULT2A1 is used in various biochemical assays to study steroid metabolism and drug interactions.
