STAT3 Human
Signal transducer and activator of transcription 3 isoform 1, STAT3, ADMIO, DMIO1, APRF, HIES.
Greater than 90.0% as determined by SDS-PAGE.
Description
STAT3 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain (1-770 a.a.) and fused to a 6 aa His Tag at C-terminus containing a total of 776 amino acids and having a molecular mass of 88.8kDa.STAT3 shows multiple bands between 70-100kDa on SDS-PAGE, reducing conditions and purified by proprietary chromatographic techniques.
Product Specs
Signal transducer and activator of transcription 3 isoform 1, STAT3, ADMIO, DMIO1, APRF, HIES.
MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAYAASKE SHATLVFHNL LGEIDQQYSR FLQESNVLYQ HNLRRIKQFLQSRYLEKPME IARIVARCLW EESRLLQTAA TAAQQGGQAN HPTAAVVTEK QQMLEQHLQD VRKRVQDLEQ KMKVVENLQD DFDFNYKTLK SQGDMQDLNG NNQSVTRQKM QQLEQMLTAL DQMRRSIVSE LAGLLSAMEY VQKTLTDEEL ADWKRRQQIA CIGGPPNICL DRLENWITSLAESQLQTRQQ IKKLEELQQK VSYKGDPIVQ HRPMLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTTKVR LLVKFPELNY QLKIKVCIDK DSGDVAALRG SRKFNILGTN TKVMNMEESN NGSLSAEFKH LTLREQRCGN GGRANCDASL IVTEELHLIT FETEVYHQGLKIDLETHSLP VVVISNICQM PNAWASILWY NMLTNNPKNV NFFTKPPIGT WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGVNYS GCQITWAKFC KENMAGKGFS FWVWLDNIID LVKKYILALW NEGYIMGFIS KERERAILST KPPGTFLLRF SESSKEGGVT FTWVEKDISGKTQIQSVEPY TKQQLNNMSF AEIIMGYKIM DATNILVSPL VYLYPDIPKE EAFGKYCRPE SQEHPEADPG SAAPYLKTKF ICVTPTTCSN TIDLPMSPRT LDSLMQFGNN GEGAEPSAGG QFESLTFDME LTSECATSPM HHHHHH.
Product Science Overview
STAT3 is a cytoplasmic protein that becomes activated through phosphorylation in response to cytokines and growth factors. Upon activation, STAT3 dimerizes and translocates to the nucleus, where it binds to specific DNA sequences to regulate gene expression. The activation of STAT3 is primarily mediated by the Janus kinase (JAK) family of tyrosine kinases .
STAT3 plays a pivotal role in numerous biological functions:
- Cell Proliferation and Survival: STAT3 promotes cell growth and survival by regulating the expression of genes involved in these processes.
- Immune Response: It modulates the immune response by influencing the activity of various immune cells.
- Angiogenesis: STAT3 is involved in the formation of new blood vessels, a process crucial for tumor growth and wound healing .
Constitutive activation of STAT3 is associated with various diseases, particularly cancers. It is frequently activated in many human cancers, including solid tumors and hematologic malignancies. This persistent activation contributes to oncogenesis by promoting cell proliferation, inhibiting apoptosis, and facilitating angiogenesis .
Recombinant human STAT3 is a form of the protein produced through recombinant DNA technology. This allows for the production of large quantities of STAT3 for research and therapeutic purposes. Recombinant STAT3 is used in various studies to understand its function and to develop STAT3-targeted therapies .
