SOSTDC1 Human
Sclerostin Domain Containing 1 Human Recombinant
Cat. No.
BT19741
Source
Escherichia Coli.
Synonyms
Sclerostin domain-containing protein 1, Ectodermal BMP inhibitor, Ectodin, Uterine sensitization-associated gene 1 protein, USAG-1, SOSTDC1, USAG1, CDA019.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 85.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
SOSTDC1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 206 amino acids (24-206 a.a) and having a molecular mass of 23kDa.
SOSTDC1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
SOSTDC1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Introduction
Sclerostin Domain Containing 1 (SOSTDC1), a member of the sclerostin family, is a secreted N-glycosylated protein with a C-terminal cystine knot-like domain. Functioning as a bone morphogenetic protein (BMP) antagonist, SOSTDC1 directly interacts with BMPs, preventing them from binding to their receptors. This interaction regulates BMP signaling pathways involved in cellular processes like proliferation, differentiation, and apoptosis. SOSTDC1 is also believed to play a role in endometrial receptivity for implantation and sensitization for the decidual cell reaction. It enhances Wnt signaling while inhibiting TGF-beta signaling. Additionally, SOSTDC1 directly antagonizes the activity of BMP2, BMP4, BMP6, and BMP7 in a dose-dependent manner.
Description
Recombinant human SOSTDC1, produced in E. coli, is a single, non-glycosylated polypeptide chain comprising 206 amino acids (24-206 a.a). It has a molecular mass of 23 kDa. The protein consists of SOSTDC1 fused to a 23 amino acid His-tag at the N-terminus. It is purified using proprietary chromatographic techniques.
Physical Appearance
A sterile, colorless solution.
Formulation
The SOSTDC1 protein solution (1 mg/ml) is supplied in a buffer containing 20 mM Tris-HCl (pH 8.0), 0.4 M urea, and 10% glycerol.
Stability
For short-term storage (up to 2-4 weeks), keep at 4°C. For extended storage, freeze at -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Avoid repeated freeze-thaw cycles.
Purity
Purity is determined to be greater than 85.0% by SDS-PAGE analysis.
Synonyms
Sclerostin domain-containing protein 1, Ectodermal BMP inhibitor, Ectodin, Uterine sensitization-associated gene 1 protein, USAG-1, SOSTDC1, USAG1, CDA019.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSFKNDATE ILYSHVVKPV PAHPSSNSTL NQARNGGRHF SNTGLDRNTR VQVGCRELRS TKYISDGQCT SISPLKELVC AGECLPLPVL PNWIGGGYGT KYWSRRSSQE WRCVNDKTRT QRIQLQCQDG STRTYKITVV TACKCKRYTR QHNESSHNFE SMSPAKPVQH HRERKRASKS SKHSMS.
Product Science Overview
Function and Mechanism
SOSTDC1 functions primarily as a bone morphogenetic protein (BMP) antagonist . It directly associates with BMPs, preventing them from binding to their receptors. This regulation of BMP signaling is crucial during cellular processes such as proliferation, differentiation, and programmed cell death . Additionally, SOSTDC1 enhances Wnt signaling and inhibits TGF-beta signaling, further influencing cellular activities .
Biological Significance
The protein plays a significant role in various biological processes, including:
- Bone Homeostasis: SOSTDC1 is involved in the regulation of bone density and structure. Mutations in the SOST gene can lead to conditions like sclerosteosis and van Buchem disease, which are characterized by progressive skeletal overgrowth .
- Tooth Regeneration: Inhibition of USAG-1 has been explored as a potential method for stimulating tooth regeneration, making it of interest in the field of dentistry .
- Endometrial Receptivity: SOSTDC1 may also be involved in the onset of endometrial receptivity for implantation and sensitization for the decidual cell reaction .
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