SNTA1 Antibody

Syntrophin, Alpha 1, Mouse Anti Human
Cat. No.
BT412
Source
Synonyms
Alpha-1-syntrophin, 59 kDa dystrophin-associated protein A1 acidic component 1, Pro-TGF-alpha cytoplasmic domain-interacting protein 1, TACIP1, Syntrophin-1, SNTA1, SNT1, LQT12, dJ1187J4.5.
Appearance
Sterile filtered colorless solution.
Purity
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

Product Specs

Introduction
As a member of the syntrophin family, SNTA1 plays a crucial role as a peripheral membrane protein. It interacts with dystrophin and dystrophin-related proteins, which are essential components of muscle fiber structure. Notably, SNTA1 deficiency is linked to Duchenne Muscular Dystrophy. This protein functions as a cytoplasmic peripheral membrane scaffold protein within the dystrophin-associated protein complex. Its N-terminal PDZ domain interacts with the C-terminus of the cardiac sodium channel Nav1.5's pore-forming alpha subunit (SCN5A). Furthermore, SNTA1 connects cardiac sodium channels to the nitric oxide synthase-PMCA4b complex in cardiomyocytes. The SNTA1 gene is significant due to its association with Long-QT syndrome (LQT), a disorder linked to sudden cardiac death from arrhythmia, and sudden infant death syndrome (SIDS). Its role extends to the neuromuscular junction, where it associates with dystrophin and its related proteins, influencing intracellular calcium ion levels in muscle tissue.
Physical Appearance
The product appears as a clear, colorless liquid that has been sterilized by filtration.
Formulation
This product is supplied at a concentration of 1mg/ml and contains the following components: PBS (pH 7.4), 10% Glycerol, and 0.02% Sodium Azide.
Storage Procedures
For optimal storage, keep the product at 4°C for up to 1 month. For extended storage, it is recommended to store at -20°C. Repeated freezing and thawing cycles should be avoided.
Stability / Shelf Life
The product remains stable for 12 months when stored at -20°C and for 1 month when stored at 4°C.
Applications
This antibody has been rigorously tested and validated for its specificity and reactivity in ELISA and Western blot analyses. However, optimal working dilutions should be determined empirically for each specific application. As a starting point, a dilution of 1:1000 is recommended.
Synonyms
Alpha-1-syntrophin, 59 kDa dystrophin-associated protein A1 acidic component 1, Pro-TGF-alpha cytoplasmic domain-interacting protein 1, TACIP1, Syntrophin-1, SNTA1, SNT1, LQT12, dJ1187J4.5.
Type
Mouse Anti Human Monoclonal.
Clone
PAT1E1A.
Immunogen
Anti-human SNTA1 mAb, clone PAT1E1A, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human SNTA1 protein 1-505 amino acids purified from E. coli.
Ig Subclass
Mouse IgG2b heavy chain and Kappa light chain.

Product Science Overview

Introduction

Syntrophin alpha 1 is a protein that plays a crucial role in the structural integrity and function of muscle cells. It is part of the syntrophin family, which includes several isoforms that interact with dystrophin and other dystrophin-associated proteins. These interactions are essential for maintaining the stability of the muscle cell membrane.

Structure and Function

Syntrophin alpha 1 is a peripheral membrane protein that is associated with the dystrophin-glycoprotein complex (DGC). The DGC is a multi-protein complex that links the cytoskeleton of a muscle fiber to the extracellular matrix, providing structural support and stability. Syntrophin alpha 1 specifically binds to the C-terminal region of dystrophin, facilitating the assembly of the DGC.

Role in Disease

Mutations or deficiencies in dystrophin or its associated proteins, including syntrophin alpha 1, can lead to muscular dystrophies. Duchenne Muscular Dystrophy (DMD) and Becker Muscular Dystrophy (BMD) are two well-known conditions associated with dystrophin deficiencies. In these diseases, the absence or reduction of dystrophin disrupts the DGC, leading to muscle fiber damage and progressive muscle weakness.

Mouse Anti Human Syntrophin Alpha 1 Antibody

The mouse anti human syntrophin alpha 1 antibody is a monoclonal antibody developed to specifically target and bind to the human syntrophin alpha 1 protein. This antibody is widely used in research to study the expression, localization, and function of syntrophin alpha 1 in various tissues and under different physiological and pathological conditions.

Applications in Research

The mouse anti human syntrophin alpha 1 antibody is utilized in several scientific applications, including:

  • Western Blotting (WB): To detect and quantify syntrophin alpha 1 protein levels in tissue samples.
  • Immunocytochemistry (ICC): To visualize the localization of syntrophin alpha 1 within cells.
  • Immunohistochemistry (IHC): To study the distribution of syntrophin alpha 1 in tissue sections.
  • Flow Cytometry: To analyze the expression of syntrophin alpha 1 on the cell surface or within cells.

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Source
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