SNCG Antibody

Gamma-Synuclein, Polyclonal Rabbit Anti-Human Antibody
Cat. No.
BT5992
Source
Synonyms
Gamma-synuclein, Persyn, Breast cancer-specific gene 1 protein, Synoretin, SR, SNCG, BCSG1, PERSYN, PRSN, g-Synuclein.
Appearance
Sterile filtered colorless solution.
Purity
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Shipped with Ice Packs
In Stock
Quick Inquiry

Description

Product Specs

Introduction
γ-synuclein (Originally known as a breast cancer specific gene product, BCSG1) is an acidic neuronal protein of 127 amino acids. Gamma-Synuclein is a member of the Synuclein protein family, which is believed to be involved in the pathogenesis of neurodegenerative diseases. High levels of Gamma-Synuclein have been found in advanced breast carcinomas suggesting a correlation between overexpression of SNCG and breast tumor development. Synuclein-Gamma is found mostly in the peripheral nervous system (in primary sensory neurons, sympathetic neurons, and motor neurons) and retina. SNCG is also identified in the brain, ovarian tumors, and in the olfactory epithelium. SNCG expression in breast tumors is a marker for tumor progression. A modification in the expression of gamma-synuclein has been detected in the retina of Alzheimer's patients.
Physical Appearance
Sterile filtered colorless solution.
Formulation
1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
Storage Procedures
For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.
Stability / Shelf Life
12 months at -20°C. 1 month at 4°C.
Applications
γ-Synuclein antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 2,000. Recommended starting dilution is 1:1,000.
Synonyms
Gamma-synuclein, Persyn, Breast cancer-specific gene 1 protein, Synoretin, SR, SNCG, BCSG1, PERSYN, PRSN, g-Synuclein.
Type
Polyclonal Rabbit Antibody.
Immunogen
Recombinant human γ-Synuclein amino acids 1-127 purified from E. coli.

Product Science Overview

Introduction

Gamma-synuclein, also known as SNCG, is a member of the synuclein family of proteins, which includes alpha-synuclein and beta-synuclein. These proteins are predominantly expressed in the nervous system and have been implicated in the pathogenesis of neurodegenerative diseases, such as Parkinson’s disease and Alzheimer’s disease .

Gamma-Synuclein (SNCG)

Gamma-synuclein is encoded by the SNCG gene and is also referred to as breast cancer-specific gene 1 protein (BCSG1), persyn, and synoretin . It is abundantly expressed in the brain, particularly in the presynaptic terminals of neurons . Gamma-synuclein has been associated with various cellular functions, including synaptic plasticity and neurotransmitter release. Additionally, mutations and overexpression of gamma-synuclein have been linked to the development of breast tumors .

Polyclonal Rabbit Anti-Human Antibody

Polyclonal antibodies are produced by immunizing animals, such as rabbits, with an antigen. In this case, the antigen is gamma-synuclein. The immune system of the rabbit generates a diverse population of antibodies that recognize multiple epitopes on the gamma-synuclein protein. These antibodies are then collected from the rabbit’s serum and purified for use in various research applications .

Applications

The polyclonal rabbit anti-human gamma-synuclein antibody is widely used in scientific research for the detection and study of gamma-synuclein in various biological samples. Some common applications include:

  • Western Blotting (WB): Used to detect gamma-synuclein protein levels in tissue and cell lysates.
  • Immunohistochemistry (IHC-P): Used to visualize gamma-synuclein expression in paraffin-embedded tissue sections.
  • Immunocytochemistry (ICC/IF): Used to study the localization of gamma-synuclein in cultured cells.
  • Enzyme-Linked Immunosorbent Assay (ELISA): Used to quantify gamma-synuclein levels in biological fluids .

Quick Inquiry

Personal Email Detected
Please use an institutional or corporate email address for inquiries. Personal email accounts ( such as Gmail, Yahoo, and Outlook) are not accepted. *

Category

Service

Related Products

SNCG Human
Gamma-Synuclein Human Recombinant
Cat. No.
BT10165
Source
Escherichia Coli.
THE BIOTEK
THE BioTek is a global biotech company offering highly purified proteins for research in cancer, apoptosis, development, endocrinology, immunology, neuroscience, proteases, and stem cells.
  • Contact
  • Address: 1925 E Maple Ave, El Segundo, CA 90245 United States
  • Phone : +1 201-285-7826
  • Email : info@thebiotek.com
  • Hours : Mon.-Fri. 9:00 AM - 5:00 PM
© Copyright 2024 Thebiotek. All Rights Reserved.