SLURP1 Human Monomer
Description
Product Specs
Product Science Overview
The Secreted LY6/PLAUR Domain Containing 1 Monomer, also known as SLURP1, is a protein encoded by the SLURP1 gene. This protein is a member of the Ly6/uPAR family, which is characterized by a distinct disulfide bridge pattern creating the three-finger Ly6/uPAR (LU) domain . The SLURP1 protein is secreted and lacks a GPI-anchoring signal sequence, distinguishing it from other members of the Ly6/uPAR family .
The SLURP1 gene is located on chromosome 8 in humans and is part of a cluster of genes encoding Ly6/uPAR family proteins . The protein encoded by this gene contains an 80 amino acid LU domain with ten cysteines arranged in a specific spacing pattern, allowing the formation of distinct disulfide bridges . This structure is crucial for the protein’s function and stability.
SLURP1 has been implicated in several biological processes, including:
- Antitumor Activity: SLURP1 is thought to possess antitumor properties, although the exact mechanisms are still under investigation .
- Skin Differentiation: It serves as a marker of late differentiation in the skin and is involved in maintaining the physiological and structural integrity of the keratinocyte layers .
- Modulation of Nicotinic Acetylcholine Receptors (nAChRs): SLURP1 can down-regulate keratinocyte proliferation by modulating nAChR activity. It inhibits alpha-7-dependent nAChR currents in an allosteric manner .
- Immunomodulatory Function: In T cells, SLURP1 may regulate intracellular calcium signaling, and it seems to have an immunomodulatory role in the cornea .
Recombinant SLURP1 is produced using recombinant DNA technology, which involves inserting the SLURP1 gene into an expression system to produce the protein in vitro. This recombinant form is used in various research applications to study its function and potential therapeutic uses.
