SGCD Human

Sarcoglycan Delta is a transmembrane glycoprotein with a small intracellular domain and a single transmembrane hydrophobic domain . It shows about 70% identity at the amino acid level to both human and rabbit gamma-sarcoglycan (SGCG) . The protein is expressed most abundantly in skeletal and cardiac muscle .

The gene encoding Sarcoglycan Delta is located on chromosome 5q33. The protein’s gene ID is 6444, and its UniProt ID is Q92629 . Mutations in this gene have been associated with autosomal recessive limb-girdle muscular dystrophy (LGMD) and dilated cardiomyopathy . These mutations can lead to the disruption of the sarcoglycan complex, resulting in muscle weakness and degeneration.

Recombinant Human Sarcoglycan Delta is typically produced in E. coli and is often tagged with a His-tag for purification purposes . The recombinant protein is used in various research applications, including ELISA, Western Blot (WB), and Immunoprecipitation (IP) . The biological activity of the recombinant protein is determined by its binding ability in functional assays .

Recombinant Sarcoglycan Delta is valuable in studying the molecular mechanisms underlying muscular dystrophies and cardiomyopathies. It is also used to investigate the interactions within the dystrophin-glycoprotein complex and to develop potential therapeutic strategies for muscle-related diseases .

The recombinant protein is usually stored at -20°C for long-term use and should be aliquoted to avoid freeze-thaw cycles . It is formulated in a buffer containing Tris-HCl, urea, and glycerol to maintain its stability .