SGCD Antibody
Description
Product Specs
Product Science Overview
Sarcoglycan Delta (SGCD) is a protein that plays a crucial role in the structural integrity of muscle cells. It is one of the four known components of the sarcoglycan complex, which is a subcomplex of the dystrophin-glycoprotein complex (DGC). The DGC forms a link between the F-actin cytoskeleton and the extracellular matrix, providing stability to muscle fibers during contraction and relaxation .
Sarcoglycan Delta is a transmembrane protein that is part of the sarcoglycan complex, which includes alpha, beta, gamma, and delta sarcoglycans. These proteins are asparagine-linked glycosylated proteins with single transmembrane domains . The sarcoglycan complex is essential for maintaining the integrity of the muscle cell membrane, preventing damage from mechanical stress .
The SGCD gene, located on chromosome 5, encodes the delta component of the sarcoglycan complex. This protein is expressed most abundantly in skeletal and cardiac muscle . Mutations in the SGCD gene have been associated with autosomal recessive limb-girdle muscular dystrophy (LGMD) and dilated cardiomyopathy .
The mouse anti-human Sarcoglycan Delta antibody is used in various research applications, including Western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA) . This antibody is valuable for detecting SGCD in mouse, rat, and human samples, making it a versatile tool for studying the protein’s expression and function .
Mutations in the SGCD gene can lead to limb-girdle muscular dystrophy type 2F (LGMD2F), a condition characterized by progressive weakness and wasting of the proximal limb muscles . This disorder often involves cardiac complications, highlighting the importance of SGCD in both skeletal and cardiac muscle function .
Research on sarcoglycanopathies, including those caused by SGCD mutations, has provided insights into the molecular pathogenesis of these disorders. Understanding the role of SGCD in muscle cell stability has opened avenues for potential therapeutic interventions . For instance, strategies to rescue misfolded sarcoglycans and assist their maturation along the endoplasmic reticulum (ER) secretory pathway are being explored .
