SFRP5 Human

Secreted Frizzled-Related Protein 5 Human Recombinant
Cat. No.
BT20611
Source
Escherichia Coli.
Synonyms
Secreted Frizzled-Related Protein 5, SARP3, Secreted Apoptosis Related Protein 3, Secreted Apoptosis-Related Protein 3, Frizzled-Related Protein 1b, FRP-1b, SARP-3, SFRP-5, FRP1B, SFRP5.
Appearance
Sterile Filtered clear solution.
Purity
Greater than 85.0% as determined by SDS-PAGE.
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

SFRP5 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 311 amino acids (30-317 a.a) and having a molecular mass of 35kDa.
SFRP5 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction
Secreted Frizzled-Related Protein 5, also known as SFRP5, is a member of the SFRP family. This family is characterized by a cysteine-rich domain that shares homology with the putative Wnt-binding site found in Frizzled proteins. SFRPs function as soluble regulators of Wnt signaling pathways. Both SFRP5 and SFRP1 have been implicated in regulating the polarity of photoreceptor cells within the retina. SFRP5 exhibits high expression levels in the retinal pigment epithelium and moderate expression levels in the pancreas.
Description
Recombinant human SFRP5, produced in E. coli, is a single, non-glycosylated polypeptide chain comprising 311 amino acids (30-317 a.a.). It has a molecular weight of 35 kDa. The SFRP5 protein is fused to a 23 amino acid His-tag at its N-terminus and is purified using proprietary chromatographic techniques.
Physical Appearance
Clear, sterile-filtered solution.
Formulation
The SFRP5 protein solution is provided at a concentration of 1 mg/ml in a buffer containing 20 mM Tris-HCl (pH 8.0) and 10% glycerol.
Stability
For short-term storage (2-4 weeks), the product can be stored at 4°C. For extended storage, it is recommended to freeze the product at -20°C. The addition of a carrier protein (0.1% HSA or BSA) is advised for long-term storage. Repeated freeze-thaw cycles should be avoided.
Purity
The purity of the SFRP5 protein is greater than 85.0%, as determined by SDS-PAGE analysis.
Synonyms
Secreted Frizzled-Related Protein 5, SARP3, Secreted Apoptosis Related Protein 3, Secreted Apoptosis-Related Protein 3, Frizzled-Related Protein 1b, FRP-1b, SARP-3, SFRP-5, FRP1B, SFRP5.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSEEYDYYG WQAEPLHGRS YSKPPQCLDI PADLPLCHTV GYKRMRLPNL LEHESLAEVK QQASSWLPLL AKRCHSDTQV FLCSLFAPVC LDRPIYPCRS LCEAVRAGCA PLMEAYGFPW PEMLHCHKFP LDNDLCIAVQ FGHLPATAPP VTKICAQCEM EHSADGLMEQ MCSSDFVVKM RIKEIKIENG DRKLIGAQKK KKLLKPGPLK RKDTKRLVLH MKNGAGCPCP QLDSLAGSFL VMGRKVDGQL LLMAVYRWDK KNKEMKFAVK FMFSYPCSLY YPFFYGAAEP H.

Product Science Overview

Expression and Function

SFRP5 is highly expressed in the retinal pigment epithelium and moderately expressed in the pancreas . It has been implicated in several physiological and pathological processes, including the regulation of photoreceptor cell polarity in the retina . Additionally, SFRP5 is known to have anti-inflammatory properties and plays a role in metabolic regulation .

Role in Cardiovascular Health

Recent studies have highlighted the protective role of SFRP5 in cardiovascular health. For instance, SFRP5 has been shown to protect against cardiac rupture and improve cardiac function by inhibiting mitochondrial dysfunction . Overexpression of SFRP5 in mouse models of myocardial infarction (MI) has been associated with reduced infarct size, decreased cardiomyocyte apoptosis, and improved left ventricular function . These findings suggest that SFRP5 may have therapeutic potential in the treatment of ischemic heart disease and heart failure .

Role in Obesity and Metabolic Disorders

SFRP5 is also an important player in the context of obesity and metabolic disorders. It is an anti-inflammatory adipokine that has been implicated in the pathophysiology of obesity and its metabolic complications . Studies have shown that SFRP5 levels are inversely associated with obesity and related metabolic parameters . In children and adolescents, higher levels of SFRP5 have been associated with better metabolic health outcomes .

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THE BioTek is a global biotech company offering highly purified proteins for research in cancer, apoptosis, development, endocrinology, immunology, neuroscience, proteases, and stem cells.
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