SFRP4 Human, sf9
Description
Product Specs
Product Science Overview
The SFRP4 gene is located on chromosome 7 (7p14.1) in humans . The protein encoded by this gene is involved in several biological processes such as cell differentiation, regulation of Wnt signaling pathways, and apoptosis . The protein structure includes a cysteine-rich domain that is essential for its function as a Wnt antagonist .
SFRP4 plays a significant role in modulating Wnt signaling pathways, which are critical for embryonic development and maintaining adult tissue homeostasis . By binding to Wnt proteins, SFRP4 prevents them from interacting with their Frizzled receptors, thereby inhibiting the Wnt signaling cascade . This modulation is vital for processes such as bone morphogenesis, phosphate ion homeostasis, and regulation of cell proliferation .
SFRP4 has been implicated in various diseases and conditions. For instance, it is associated with Pyle disease, a genetic disorder characterized by defective bone remodeling and increased bone fragility . Additionally, SFRP4 is a hub gene in Type 2 Diabetes-associated gene coexpression modules in human islets, where it reduces glucose-induced insulin secretion . Elevated levels of SFRP4 have been observed in serum several years before the clinical diagnosis of Type 2 Diabetes .
Recent studies have highlighted the role of SFRP4 in cancer biology. It has been shown to chemo-sensitize cancer stem cells derived from human breast, prostate, and ovary tumor cell lines . By downregulating stemness genes and upregulating pro-apoptotic markers, SFRP4 enhances the efficacy of chemotherapeutic drugs such as doxorubicin and cisplatin . This property makes SFRP4 a potential therapeutic target for improving cancer treatment outcomes .
The recombinant form of SFRP4 (Human Recombinant, sf9) is produced using the Sf9 insect cell expression system . This system is commonly used for producing recombinant proteins due to its ability to perform post-translational modifications similar to those in mammalian cells . The recombinant SFRP4 retains its functional properties and is used in various research applications to study its role in Wnt signaling and disease mechanisms .
