SERPINC1 Human
Description
SERPINC1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Belonging to the serpin superfamily, Serpin Peptidase Inhibitor, Clade C Member 1 (SERPINC1) functions as a plasma protease inhibitor. SERPINC1 plays a crucial role in regulating the blood coagulation cascade by inhibiting thrombin, along with other activated serine proteases involved in this pathway. Specifically, SERPINC1 inhibits Thrombin and Factors IXa, Xa, and XIa. Deficiencies in SERPINC1 can lead to antithrombin III (ATIII) deficiency, an autosomal dominant disorder that may result in hereditary thrombophilia, a condition characterized by an increased tendency for blood clotting.
Product Science Overview
Serpin Peptidase Inhibitor, Clade C Member 1, also known as Antithrombin III (ATIII), is a crucial protein in the regulation of blood coagulation. It belongs to the serine protease inhibitor (serpin) superfamily, which includes proteins that inhibit proteases by trapping them in a stable complex. This article delves into the background, structure, function, and clinical significance of this important protein.
The gene encoding Serpin Peptidase Inhibitor, Clade C Member 1, is located on chromosome 1q25.1 . The protein is synthesized in the liver and secreted into the bloodstream. It consists of 432 amino acids, including six cysteines that form three disulfide bonds . The protein has four glycosylation sites, which are crucial for its stability and function .
The protein contains two important functional domains:
Antithrombin III is the most important inhibitor of thrombin and other coagulation proteinases . It regulates clot formation by inhibiting thrombin activity directly and interfering with earlier stages of the clotting cascade . The heparin-antithrombin mechanism is one of the principal natural anticoagulant systems that exert damping effects on various steps of the coagulation cascade .
Inherited antithrombin III deficiency is a risk factor for the early development of venous thromboembolism . This condition, known as Thrombophilia 7, can lead to severe complications if not managed properly . Additionally, recent studies have shown that Serpin Peptidase Inhibitor, Clade C Member 1, acts as a tumor suppressor in hepatocellular carcinoma by inducing apoptosis and blocking macrophage polarization .
Human recombinant Antithrombin III is produced using recombinant DNA technology. This involves inserting the gene encoding the protein into a suitable expression system, such as bacteria or mammalian cells, to produce the protein in large quantities. Recombinant Antithrombin III is used in clinical settings to treat patients with hereditary antithrombin deficiency and to prevent thromboembolic events during surgeries and childbirth.
