SCG5 Human
Secretogranin-V Human Recombinant
Cat. No.
BT21036
Source
Escherichia Coli.
Synonyms
7B2, SgV, P7B2, SGNE1, Secretogranin-5, Secretory granule endocrine protein I.
Appearance
Sterile Filtered colorless liquid formulation.
Purity
Greater than 85% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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In Stock 
Description
SCG5 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 195 amino acids (27-212 a.a.) and having a molecular mass of 22 kDa. SCG5 is fused to a 8 amino acid His tag at C-terminus and purified by standard chromatography techniques.
Product Specs
Introduction
SCG5, also known as 7B2 protein, is found in neuroendocrine tissues. It acts as a chaperone protein for the proprotein convertase PC2, playing a crucial role in activating the PC2 enzyme.
Description
Recombinant human SCG5, produced in E. coli, is a single, non-glycosylated polypeptide chain consisting of 195 amino acids (27-212 a.a.) with a molecular weight of 22 kDa. An 8 amino acid His tag is fused to the C-terminus of SCG5, which is purified using standard chromatography methods.
Physical Appearance
The product is a sterile, colorless liquid.
Formulation
The solution contains 0.5mg/ml of SCG5 in a buffer consisting of 20mM Tris-HCl (pH 8), 0.1mM PMSF, 1mM DTT, 0.1M NaCl, and 20% glycerol.
Stability
For short-term storage (2-4 weeks), keep at 4°C. For longer storage, freeze at -20°C. Avoid repeated freezing and thawing.
Purity
The purity is determined to be higher than 85% based on SDS-PAGE analysis.
Synonyms
7B2, SgV, P7B2, SGNE1, Secretogranin-5, Secretory granule endocrine protein I.
Source
Escherichia Coli.
Amino Acid Sequence
MYSPRTPDRV SEADIQRLLH GVMEQLGIAR PRVEYPAHQA MNLVGPQSIE GGAHEGLQHL GPFGNIPNIV AELTGDNIPK DFSEDQGYPD
PPNPCPVGKT ADDGCLENTP DTAEFSREFQ LHQHLSDPEH DYPGLGKWNK KLLYEKMKGG ERRKRRSVNP YLQGQRLDNV VAKKSVPHFS
DEDKDPELEH HHHHH.
PPNPCPVGKT ADDGCLENTP DTAEFSREFQ LHQHLSDPEH DYPGLGKWNK KLLYEKMKGG ERRKRRSVNP YLQGQRLDNV VAKKSVPHFS
DEDKDPELEH HHHHH.
Product Science Overview
Structure and Expression
Secretogranin-V is a protein encoded by the SCG5 gene. The recombinant form of this protein is typically produced in E. coli and includes a C-terminal His-tag for purification purposes . The amino acid sequence of the recombinant human Secretogranin-V corresponds to residues 27-212 of the native protein .
Biological Functions
Clinical Significance
Recent studies have highlighted the potential of Secretogranin-V as a diagnostic and prognostic biomarker for pancreatic adenocarcinomas . Machine learning models have identified SCG5 as a key gene whose expression is significantly reduced in pancreatic cancer tissues compared to normal tissues . Furthermore, plasma levels of SCG5 have been correlated with body mass index and age, suggesting a role in systemic energy metabolism .
Applications
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