RND3 Human
Description
Product Specs
Product Science Overview
The Rho family of GTPases is a subfamily of the Ras superfamily of small (~21 kDa) signaling G proteins. These proteins play a crucial role in regulating various aspects of intracellular actin dynamics, which are essential for numerous cellular functions such as morphogenesis, polarity, movement, cell division, gene expression, and cytoskeleton reorganization .
The identification of the Rho family of GTPases began in the mid-1980s. The first member, RhoA, was isolated in 1985, followed by Rac1 and Rac2 in 1989, and Cdc42 in 1990 . Over time, additional members were identified, leading to the classification of the Rho family into 20 members distributed across 8 subfamilies: Rho, Rnd, RhoD/F, RhoH, Rac, Cdc42, RhoU/V, and RhoBTB .
Rho GTPases act as molecular switches by cycling between an inactive GDP-bound state and an active GTP-bound state. This switching mechanism allows them to interact with various downstream effectors, thereby regulating a multitude of biochemical processes . The Rho family members are involved in the formation of cellular projections such as filopodia, lamellipodia, and stress fibers, which are critical for cell movement and morphology .
Rho Family GTPase 3, also known as RhoG, is one of the members of the Rho family. It shares structural and functional similarities with other Rho GTPases and is involved in various cellular processes. RhoG has been shown to regulate actin cytoskeleton dynamics, cell migration, and cell signaling pathways .
Human recombinant RhoG is a laboratory-produced version of the naturally occurring RhoG protein. Recombinant proteins are typically produced using genetic engineering techniques, where the gene encoding the protein is inserted into an expression system, such as bacteria or yeast, to produce large quantities of the protein. This recombinant form is used in various research applications to study the protein’s function, interactions, and potential therapeutic uses.
RhoG and other Rho GTPases are of significant interest in biomedical research due to their roles in various cellular processes and their association with human diseases. Altered signaling through Rho GTPases has been implicated in the progression of several malignancies, making them potential targets for therapeutic intervention . Understanding the regulation and function of RhoG can provide insights into the mechanisms underlying these diseases and aid in the development of targeted therapies.
