RLN2 Human, Sf9
Sf9, Baculovirus cells.
Relaxin 2, Relaxin, Ovarian, Of Pregnancy, Prorelaxin H2, Relaxin H2, H2-Preprorelaxin, Relaxin 2 (H2), BA12D24.1.1, BA12D24.1.2, H2-RLX, RLXH2, H2.
Description
RLN2 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 170 amino acids (25-185a.a.) and having a molecular mass of 19.3kDa (Molecular size on SDS-PAGE will appear at approximately 18-28kDa).
RLN2 is expressed with a 6 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.
Product Specs
Relaxin 2, Relaxin, Ovarian, Of Pregnancy, Prorelaxin H2, Relaxin H2, H2-Preprorelaxin, Relaxin 2 (H2), BA12D24.1.1, BA12D24.1.2, H2-RLX, RLXH2, H2.
Sf9, Baculovirus cells.
ADPDSWMEEV IKLCGRELVR AQIAICGMST WSKRSLSQED APQTPRPVAE IVPSFINKDT ETINMMSEFV ANLPQELKLT LSEMQPALPQ LQQHVPVLKD SSLLFEEFKK LIRNRQSEAA DSSPSELKYL GLDTHSRKKR QLYSALANKC CHVGCTKRSL ARFCHHHHHH.
Product Science Overview
Relaxin-2 is a peptide hormone that belongs to the relaxin family, which also includes relaxin-1, relaxin-3, and other related peptides. It is structurally similar to insulin and is the only relaxin that circulates in the blood. Relaxin-2 plays a crucial role in various physiological processes, including reproduction, cardiovascular function, and tissue remodeling.
Relaxin-2 is composed of two peptide chains, A and B, linked by disulfide bonds. It binds specifically to the receptors RXFP1 (LGR7) and RXFP2 (LGR8), which are G protein-coupled receptors. Upon binding to these receptors, relaxin-2 activates several intracellular signaling pathways, leading to various biological effects.
Relaxin-2 has a wide range of biological effects, including:
- Vasodilation: It promotes the relaxation of blood vessels, leading to increased blood flow and reduced blood pressure.
- Antifibrotic Effects: Relaxin-2 inhibits the formation of fibrous tissue, which can help prevent and reverse fibrosis in organs such as the heart and kidneys.
- Angiogenesis: It stimulates the formation of new blood vessels, which is essential for tissue repair and regeneration.
- Anti-inflammatory Effects: Relaxin-2 reduces inflammation by modulating the activity of various immune cells.
- Anti-apoptotic Effects: It prevents programmed cell death, thereby protecting cells from damage.
Recombinant human relaxin-2 is produced using the Sf9 insect cell expression system. This system involves the use of baculovirus vectors to introduce the relaxin-2 gene into Sf9 cells, which then produce the relaxin-2 protein. The recombinant protein is purified and used for various research and therapeutic applications.
Relaxin-2 has shown promise in several therapeutic areas, including:
- Heart Failure: Relaxin-2 has been investigated for its potential to treat acute heart failure. Clinical trials have shown that serelaxin, a recombinant form of relaxin-2, can improve symptoms and outcomes in patients with acute heart failure .
- Fibrosis: Relaxin-2’s antifibrotic effects make it a potential treatment for conditions characterized by excessive fibrosis, such as liver cirrhosis and pulmonary fibrosis .
- Reproductive Health: Relaxin-2 plays a role in pregnancy and childbirth by promoting the relaxation of the pelvic ligaments and cervix. It has potential applications in managing complications related to pregnancy and labor.
