RAP2B Human
Description
Product Specs
MGSSHHHHHH SSGLVPRGSH MGSMREYKVV VLGSGGVGKS ALTVQFVTGS FIEKYDPTIE DFYRKEIEVD SSPSVLEILD TAGTEQFASM RDLYIKNGQG FILVYSLVNQ QSFQDIKPMR DQIIRVKRYE RVPMILVGNK VDLEGEREVS YGEGKALAEE WSCPFMETSA KNKASVDELF AEIVRQMNYA AQPNGDEGCC SACVIL.
Product Science Overview
RAP2B is a member of the RAS oncogene family, which is known for its role in cell signaling pathways that control cell growth, differentiation, and survival. The RAS family of proteins are small GTPases that act as molecular switches, cycling between an active GTP-bound state and an inactive GDP-bound state. RAP2B, in particular, shares approximately 50% amino acid identity with classical RAS proteins and has several structural features in common with them .
The RAP2B gene is located on chromosome 3q25.2 and is intronless, meaning it does not contain introns within its coding sequence . The protein encoded by RAP2B is a small GTP-binding protein that cycles between GDP-bound inactive and GTP-bound active forms. One of the most notable differences between RAP2B and classical RAS proteins is the substitution of glutamine with threonine at the 61st amino acid position .
RAP2B is involved in several cellular processes, including cytoskeletal rearrangements, cell spreading, and membrane vesiculation in red blood cells . It plays a role in the signaling pathways of the epidermal growth factor receptor (EGFR) and muscarinic acetylcholine receptor M3 (CHRM3) through the stimulation of phospholipase C epsilon 1 (PLCE1) . Additionally, RAP2B is implicated in the regulation of protein tyrosine kinase activity, microvillus assembly, and the establishment of endothelial intestinal barriers .
RAP2B is associated with several signaling pathways, including the innate immune system and G-protein signaling cascades . It interacts with various proteins and is involved in the regulation of cell migration, protein autophosphorylation, and platelet aggregation . RAP2B’s role in these pathways highlights its importance in maintaining cellular homeostasis and responding to external stimuli.
Mutations or dysregulation of RAP2B have been linked to various diseases, including Masa Syndrome and Peroxisome Biogenesis Disorder 8B . As a member of the RAS oncogene family, RAP2B is also associated with tumorigenesis, and its expression has been observed in a variety of human tumors . Understanding the function and regulation of RAP2B is crucial for developing targeted therapies for diseases related to its dysregulation.
