RANK Mouse
Sf9, Baculovirus cells.
Tumor necrosis factor receptor superfamily member 11A, Osteoclast differentiation factor receptor, ODFR, Receptor activator of NF-KB, activator of NFKB, FEO, OFE, OSTS, PDB2, RANK, RANKLOH18CR1, CD265, CD265 antigen, OPTB7, TRANCER, LOH18CR1, receptor activator of nuclear factor-kappa B.
Greater than 90.0% as determined by SDS-PAGE.
Description
RANK Mouse Recombinant produced in Baculovirus is a single glycosylated polypeptide chain containing 426 amino acids (31-214 aa) and having a molecular mass of 47.5kDa.
RANK is fused to a 242 amino acid hIgG-His-Tag at C-terminus and purified by proprietary chromatographic techniques.
Product Specs
Tumor necrosis factor receptor superfamily member 11A, Osteoclast differentiation factor receptor, ODFR, Receptor activator of NF-KB, activator of NFKB, FEO, OFE, OSTS, PDB2, RANK, RANKLOH18CR1, CD265, CD265 antigen, OPTB7, TRANCER, LOH18CR1, receptor activator of nuclear factor-kappa B.
Sf9, Baculovirus cells.
ADLVTPPCTQ ERHYEHLGRC CSRCEPGKYL SSKCTPTSDS VCLPCGPDEY LDTWNEEDKC LLHKVCDAGK ALVAVDPGNH TAPRRCACTA GYHWNSDCEC CRRNTECAPG FGAQHPLQLN KDTVCTPCLL GFFSDVFSST DKCKPWTNCT LLGKLEAHQG TTESDVVCSS SMTLRRPPKE AQAYLPSLEP KSCDKTHTCP PCPAPELLGG PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE LTKNQVSLTC LVKGFYPSDI VEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW QQGNVFSCSV MHEALHNHYT QKSLSLSPGK HHHHHH
Product Science Overview
RANK is a type I transmembrane protein that is expressed on the surface of various cell types, including osteoclast precursors, dendritic cells, and mammary gland epithelial cells. The extracellular domain of RANK binds to its ligand, RANKL (Receptor Activator of Nuclear Factor Kappa-Β Ligand), which is also known as TRANCE, TNFSF11, or OPGL .
The primary function of RANK is to mediate the effects of RANKL. When RANKL binds to RANK, it triggers a signaling cascade that leads to the activation of NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) and other downstream pathways. This signaling is essential for:
- Osteoclast Differentiation and Activation: RANK-RANKL interaction is critical for the formation, function, and survival of osteoclasts, the cells responsible for bone resorption. This process is vital for bone remodeling and calcium homeostasis .
- Immune System Regulation: RANK signaling influences the development and function of dendritic cells, which are key players in the immune response. It also affects the formation of lymph nodes and the maturation of mammary glands during pregnancy .
Recombinant mouse RANK is produced using various expression systems, such as E. coli. The recombinant protein is typically purified to high levels of purity and is used in various research applications, including:
Recombinant mouse RANK is used extensively in research to understand its role in bone metabolism and immune regulation. It is also used to screen potential inhibitors that could be developed into drugs for treating bone-related diseases and immune disorders. The ability to produce recombinant RANK in a controlled environment allows researchers to conduct detailed studies on its structure, function, and interactions with other proteins .
